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Type: Artigo de periódico
Title: Quantification of methyldopa in human plasma by high-performance liquid chromatography-electrospray tandem mass spectrometry - Application to a bioequivalence study
Author: Oliveira, CH
Barrientos-Astigarraga, RE
Sucupira, M
Graudenz, GS
Muscara, MN
De Nucci, G
Abstract: A method based on LC-MS-MS is described for the determination of methyldopa in human plasma using dopa-phenyl-D3 as the internal standard. The method has a chromatographic run time of 5.5 min and was linear in the range of 20-5000 ng/ml. The limit of quantitation was 20 ng/ml, the intra-day precisions were 7.3, 5.4 and 4.3% and the intra-day accuracies were -8.0, -1.3 and -2.0% for 30, 600 and 3000 ng/ml, respectively. The inter-day precisions were 7.7, 0.5 and 0.7% and the inter-day accuracies were 0.2, -1.1 and -2.3%, respectively, for the above concentrations, This method was employed in a bioequivalence study of two tablet formulations of methyldopa. (C) 2002 Elsevier Science B.V. All rights reserved.
Subject: bioequivalence studies
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S1570-0232(01)00612-2
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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