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Type: Artigo de periódico
Title: Quality of life and adverse events after radiotherapy in gynecologic cancer survivors: a cohort study
Author: Vaz, AF
Conde, DM
Costa-Paiva, L
Morais, SS
Esteves, SB
Pinto-Neto, AM
Abstract: Purpose To evaluate quality of life (QOL) in gynecologic cancer survivors after radiotherapy (RT), investigate the frequency of adverse events and demonstrate an association between these symptoms and QOL. Methods A prospective cohort study of 95 women aged 21-75 years undergoing RT for gynecologic cancer was carried out. QOL was assessed by the WHOQOL-BREF before, at 4 months, 1 year and 3 years after RT and adverse events were evaluated following RT by the (CTCAE) v 3.0 scale. QOL scores were assessed by the Wilcoxon signed rank test over time. Multiple linear regression analysis was used to identify predictors of QOL. Results The most frequent adverse events were pain (64.2%) and dyspareunia (45.9%). A significant increase in QOL scores was observed in the psychological domain, general health and overall QOL. Pain was negatively associated with the physical, psychological and social relationship domains (p < 0.01); dyspareunia with the physical and social relationship (p < 0.01); decreased sexual interest with the psychological (p < 0.01). Higher family income was positively associated with the psychological domain and general health (p < 0.01). Conclusions Results suggested that QOL improved after RT in women with gynecologic cancer. Adverse events, such as pain, dyspareunia and decreased sexual interest had a negative impact on QOL.
Subject: Gynecologic cancer
Quality of life
Adverse events
Country: Alemanha
Editor: Springer Heidelberg
Citation: Archives Of Gynecology And Obstetrics. Springer Heidelberg, v. 284, n. 6, n. 1523, n. 1531, 2011.
Rights: fechado
Identifier DOI: 10.1007/s00404-011-1886-x
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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