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|Type:||Artigo de periódico|
|Title:||QSAR based on biological microcalorimetry .3. Interaction of m-alkoxyphenols and p-hydroxybenzoates with Escherichia coli|
|Abstract:||QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E, coli cells were carried out applying factorial design. Results for both series showed a linear relationship between log(dose)max and log P-o/w. Analysis of these data allows the identification of contributions toward the derived bioactivity from the parent structures (the molecule minus n-CH2 groups present in the side-chain) and the lipophilic groups, CH2. These results are discussed with respect to drug quantitative structure-relationship.|
|Subject:||evening chemistry course|
|Editor:||Soc Brasileira Quimica|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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