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Type: Artigo de periódico
Title: QSAR based on biological microcalorimetry .3. Interaction of m-alkoxyphenols and p-hydroxybenzoates with Escherichia coli
Author: Vianna, JF
Aydos, MCR
Siqueira, OS
Abstract: QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E, coli cells were carried out applying factorial design. Results for both series showed a linear relationship between log(dose)max and log P-o/w. Analysis of these data allows the identification of contributions toward the derived bioactivity from the parent structures (the molecule minus n-CH2 groups present in the side-chain) and the lipophilic groups, CH2. These results are discussed with respect to drug quantitative structure-relationship.
Subject: evening chemistry course
training teachers
Country: Brasil
Editor: Soc Brasileira Quimica
Rights: aberto
Date Issue: 1997
Appears in Collections:Unicamp - Artigos e Outros Documentos

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