Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/58409
Type: Artigo de periódico
Title: PTK2 and PTPN11 expression in myelodysplastic syndromes
Author: Lazarini, M
Machado-Neto, JA
Archangelo, LF
Mendes-Silva, BF
Bigarella, CL
Traina, F
Saad, STO
Abstract: OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. RESULTS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. CONCLUSIONS: Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domaincontaining protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors.
Subject: Myelodysplastic Syndromes
PTPN11
PTK2
FAK
SHP2
Country: Brasil
Editor: Hospital Clinicas, Univ Sao Paulo
Rights: aberto
Identifier DOI: 10.6061/clinics/2013(10)13
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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