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Type: Artigo de periódico
Title: Proteomic Analysis of Matrix of Dental Biofilm Formed under Dietary Carbohydrate Exposure
Author: Moi, GP
Cury, JA
Dombroski, TCD
Pauletti, BA
Leme, AFP
Abstract: To evaluate whether protein changes in extracellular matrix of dental biofilm are a unique property of sucrose, this in situ study was conducted using as active control glucose and fructose, the sucrose monosaccharide constituents. Proteins were analyzed by two-dimensional electrophoresis followed by LC-MS/MS after trypsin digestion. Absence or lower abundance of calcium-binding proteins and higher abundance of prolactin-induced proteins were found in biofilm formed in the presence of sucrose or its monosaccharide constituents compared with water, the negative control group. The data suggest that besides sucrose, other dietary carbohydrates may also provoke a change in the protein profile of extracellular matrix of dental biofilm formed. Copyright (C) 2012 S. Karger AG, Basel
Subject: Biofilms
Liquid chromatography-tandem mass spectrometry
Two-dimensional gel electrophoresis
Country: Suíça
Editor: Karger
Rights: fechado
Identifier DOI: 10.1159/000338246
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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