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Type: Artigo de periódico
Title: Protective immunity induced by a Trypanosoma cruzi soluble extract antigen in experimental Chagas' Disease. Role of Interferon gamma
Author: Garcia, CAAC
Oliveira, EC
Sakurada, JK
Santos, LMB
Abstract: CBA/J mice can be protected against lethal infection with Trypanosoma cruzi by treatment using T.cruzi soluble extract antigen (TCSE). In vivo administration of TCSE (400 mu g/mouse) into naive mice increased the cellular proliferative response to Con A and elevated the levels of IFN-gamma. The production of IFN-gamma was extremely important in controlling the replication of the parasite since the protective activity of TCSE was completely abrogated by in vivo treatment with an anti IFN-gamma neutralizing antibody. These results suggest that depending on the level, cytokine production results in the control of replication of the parasite in experimental Chagas' disease.
Country: EUA
Editor: Marcel Dekker Inc
Rights: fechado
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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