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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleProtective effects of L-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatinpt_BR
dc.contributor.authorCosta, RAPpt_BR
dc.contributor.authorFernandes, MPpt_BR
dc.contributor.authorde Souza-Pinto, NCpt_BR
dc.contributor.authorVercesi, AEpt_BR
unicamp.author.emailanibal@unicamp.brpt_BR
unicamp.authorCosta, Rute A. P. Fernandes, Mariana P. Vercesi, Anibal E. Univ Estadual Campinas, UNICAMP, Fac Ciencias Med, Dept Patol Clin, BR-13083887 Sao Paulo, Brazilpt_BR
unicamp.authorde Souza-Pinto, Nadja C. Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazilpt_BR
dc.subjectCell necrosispt_BR
dc.subjectMitochondrial permeability transitionpt_BR
dc.subjectL-Carnitinept_BR
dc.subjectPiracetampt_BR
dc.subjectSimvastatinpt_BR
dc.subject.wosAcetyl-l-carnitinept_BR
dc.subject.wosCoronary-heart-diseasept_BR
dc.subject.wosAlpha-lipoic Acidpt_BR
dc.subject.wosNf-kappa-bpt_BR
dc.subject.wosOxidative Stresspt_BR
dc.subject.wosFatty-acidspt_BR
dc.subject.wosProstate-cancerpt_BR
dc.subject.wosSkeletal-musclept_BR
dc.subject.wosRos Generationpt_BR
dc.subject.wosRat-brainpt_BR
dc.description.abstractMitochondrial oxidative stress followed by membrane permeability transition (MPT) has been considered as a possible mechanism for statins cytotoxicity. Statins use has been associated with reduced risk of cancer incidence, especially prostate cancer. Here we investigated the pathways leading to simvastatin-induced prostate cancer cell death as well as the mechanisms of cell death protection by L-carnitine or piracetam. These compounds are known to prevent and/or protect against cell death mediated by oxidative mitochondrial damage induced by a variety of conditions, either in vivo or in vitro. The results provide evidence that simvastatin induced MPT and cell necrosis were sensitive to either L-carnitine or piracetam in a dose-dependent fashion and mediated by additive mechanisms. When combined, L-carnitine and piracetam acted at concentrations significantly lower than they act individually. These results shed new light into both the cytotoxic mechanisms of statins and the mechanisms underlying the protection against MPT and cell death by the compounds L-carnitine and piracetam. (C) 2013 Elsevier B.V. All rights reserved.pt
dc.relation.ispartofEuropean Journal Of Pharmacologypt_BR
dc.relation.ispartofabbreviationEur. J. Pharmacol.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationFEB 15pt_BR
dc.identifier.citationEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 701, n. 41699, n. 82, n. 86, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume701pt_BR
dc.description.issuenumber41699pt_BR
dc.description.initialpage82pt_BR
dc.description.lastpage86pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.wosidWOS:000315709100012pt_BR
dc.identifier.doi10.1016/j.ejphar.2013.01.001pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipBiolab Sanus Farmaceutica Ltda (convenio Biolab/UNICAMP) [4198]pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsordocumentnumberBiolab Sanus Farmaceutica Ltda (convenio Biolab/UNICAMP) [4198]pt
dc.date.available2014-07-30T14:18:24Z
dc.date.available2015-11-26T16:37:41Z-
dc.date.accessioned2014-07-30T14:18:24Z
dc.date.accessioned2015-11-26T16:37:41Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:18:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:37:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58314
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58314-
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