Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/58314
Type: Artigo de periódico
Title: Protective effects of L-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin
Author: Costa, RAP
Fernandes, MP
de Souza-Pinto, NC
Vercesi, AE
Abstract: Mitochondrial oxidative stress followed by membrane permeability transition (MPT) has been considered as a possible mechanism for statins cytotoxicity. Statins use has been associated with reduced risk of cancer incidence, especially prostate cancer. Here we investigated the pathways leading to simvastatin-induced prostate cancer cell death as well as the mechanisms of cell death protection by L-carnitine or piracetam. These compounds are known to prevent and/or protect against cell death mediated by oxidative mitochondrial damage induced by a variety of conditions, either in vivo or in vitro. The results provide evidence that simvastatin induced MPT and cell necrosis were sensitive to either L-carnitine or piracetam in a dose-dependent fashion and mediated by additive mechanisms. When combined, L-carnitine and piracetam acted at concentrations significantly lower than they act individually. These results shed new light into both the cytotoxic mechanisms of statins and the mechanisms underlying the protection against MPT and cell death by the compounds L-carnitine and piracetam. (C) 2013 Elsevier B.V. All rights reserved.
Subject: Cell necrosis
Mitochondrial permeability transition
L-Carnitine
Piracetam
Simvastatin
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2013.01.001
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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