Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/58299
Type: Artigo de periódico
Title: Protective action against chemical-induced genotoxicity and free radical scavenging activities of Stryphnodendron adstringens ("barbatimao") leaf extracts
Author: dos Santos, PR
Ferreira, LA
Gouvea, CMCP
Abstract: The present study describes for the first time the antigenotoxic and antioxidant properties of Stryphnodendron adstringens (Mart.) Coville, Fabaceae ("barbatimao") leaves. The aqueous (AEB), water fraction (WFB) and ethanolic (EEB) extracts of leaves were obtained and they presented high content of phenolic compounds, flavonoids and proanthocyanidins. WFB and EEB inhibited the genotoxicity induced by cyclophosphamide. WFB inhibited the DNA lesion formation and both WFB and EEB decreased significantly (p<0.05) micronucleus formation. All extracts also showed high DPPH radical scavenging activity and reducing power. In conclusion all extracts presented antioxidant activity and WFB and EEB protected cells from genotoxicity induced by cyclophosphamide in rat bone marrow cells. Thus, our results support the beneficial effects of the barbatimao extracts as an anticarcinogenic agent.
Subject: antioxidant
apoptosis
cytotoxicity
DNA ladder
micronucleus
Country: Brasil
Editor: Soc Brasileira Farmacognosia
Rights: aberto
Identifier DOI: 10.1590/S0102-695X2011005000176
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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