Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/58255
Type: Artigo de periódico
Title: Thyroid hormones may influence cortical bone healing around titanium implants: A histometric study in rats
Author: Feitosa, DD
Bezerra, BD
Ambrosano, GMB
Nociti, FH
Casati, MZ
Sallum, EA
de Toledo, S
Abstract: Background: The aim of the present study was to evaluate, by histometric analysis, the influence of the thyroid hormones, triiodothyronine (T(3)) and thyroxine (T(4)), on bone healing around titanium implants inserted in rat tibiae. Methods: Forty-two male Wistar rats were randomly assigned to the experimental groups: G1 = healthy animals (control; N = 15); G2 hypothyroidism (N = 13); and G3 = hyperthyroidism (N 14). Once alterations were confirmed by total serum levels of T3 and T4, one screw-shaped titanium implant was placed in the rat tibiae. Sixty days later, the animals were sacrificed, and undecalcified sections were obtained. Bone-to-implant contact (BIC), bone area within the limits of the implant threads, and bone density in a 500-mu m-wide zone lateral to the implant were obtained separately for the cortical (zone A) and cancellous (zone B) bone regions. Results: Intergroup analysis demonstrated that thyroid hormones may significantly affect cortical bone healing around titanium implants. Hyperthyroidism significantly increased the area of newly formed bone in zone A (P<0.05), whereas hypothyroidism significantly decreased the area of newly formed bone and bone density around the implant in zone A (P<0.05) compared to the healthy group. In addition, hyperthyroidism significantly increased BIC extension in zone A compared to hypothyroidism (P<0.05). Conclusion: Thyroid hormones may influence the healing process in the cortical bone around titanium implants placed in rats, whereas cancellous bone seems to be less sensitive to changes in T3 and T4 serum levels.
Subject: bone and bones
dental implants
thyroxine
titanium
triiodothyronine
wound healing
Country: EUA
Editor: Amer Acad Periodontology
Rights: fechado
Identifier DOI: 10.1902/jop.2008.070466
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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