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Type: Artigo de periódico
Title: Therapeutic potential of biogenic silver nanoparticles in murine cutaneous leishmaniasis
Author: Rossi-Bergmann, B
Pacienza-Lima, W
Marcato, PD
De Conti, R
Duran, N
Abstract: In the last years, silver nanoparticles have appeared as novel antimicrobial agents. In this work, we evaluated the therapeutic potential of silver nanoparticles prepared by two different processes: 1) chemical synthesis (Chem-AgNP); and 2) biosynthesis from the fungus Fusarium oxysporum (Bio-AgNP), in the treatment of cutaneous leishmaniasis. When tested in vitro against Leishmania amazonensis promastigotes, Bio-AgNP was 4-fold more potent than Chem-AgNP (IC50 = 25 uM and 100 uM, respectively). In vivo studies in mice infected in the ear showed that bi-weekly intralesional injections with only 6.5 ug/Kg of body weight of Bio-AgNP during 4 weeks were equally effective as 300-fold higher doses of the reference drug amphotericin B, and more effective than 3-fold higher doses of Chem-AgNP. Contrary to the hepato- and nephrotoxicity that resulted from amphotericin B treatment, and the slight hepatotoxicity produced by Chem-AgNP, no changes in serum levels of AST, ALT and creatinine were detected with Bio-AgNP. Together, these findings show that the biogenic synthesis resulted in enhanced in vitro and in vivo antileishmanial activities, and safer silver nanoparticles as compared with the chemical synthesis.
Subject: Leaishmaniasis
silver nanoparticles
in vivo
Country: Suíça
Editor: Trans Tech Publications Ltd
Rights: fechado
Identifier DOI: 10.4028/
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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