Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/57874
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbnpt_BR
dc.contributor.authorunicampYang, Hyun Mopt_BR
dc.typeArtigopt_BR
dc.titleTheoretical assessment of the relative incidences of sensitive and resistant tuberculosis epidemic in presence of drug treatmentpt_BR
dc.title.alternativept_BR
dc.contributor.authorRaimundo, Silvia Martoranopt_BR
dc.contributor.authorYang, Hyun Mopt_BR
dc.contributor.authorVenturino, Eziopt_BR
unicamp.author.emailsilviamr@dim.fm.usp.brpt_BR
unicamp.author.emailhyunyang@ime.unicamp.brpt_BR
unicamp.author.emailezio.venturino@unito.itpt_BR
unicamp.authorRaimundo, Silvia Martorano Univ Sao Paulo, Fac Med, Disciplina Informat Med, BR-05405000 Sao Paulo, Brazilpt_BR
unicamp.authorRaimundo, Silvia Martorano LIM01 HCFMUSP, BR-05405000 Sao Paulo, Brazilpt_BR
unicamp.authorYang, Hyun Mo Univ Estadual Campinas, IMECC, DMA, Campinas, SP, Brazilpt_BR
unicamp.authorVenturino, Ezio Univ Turin, Dipartimento Matemat Giuseppe Peano, I-10123 Turin, Italypt_BR
dc.subjectTuberculose - Tratamentopt_BR
dc.subjectEpidemiologia - Modelos matemáticospt_BR
dc.subjectDrogas - Resistenciapt_BR
dc.subject.otherlanguageEpidemiology - Mathematical modelspt_BR
dc.subject.otherlanguageTuberculosis - Treatmentpt_BR
dc.subject.otherlanguageDrug resistancept_BR
dc.subject.wosMycobacterium-tuberculosispt_BR
dc.subject.wosExogenous Reinfectionpt_BR
dc.subject.wosInfectionpt_BR
dc.subject.wosModelpt_BR
dc.subject.wosEmergencept_BR
dc.subject.wosTransmissionpt_BR
dc.subject.wosDynamicspt_BR
dc.subject.wosDiseasept_BR
dc.subject.wosHivpt_BR
dc.subject.wosEvolutionpt_BR
dc.description.abstractDespite the availability of effective treatment, tuberculosis (TB) remains a major global cause of mortality. Multidrug-resistant tuberculosis (MDR-TB) is a form of TB that is resistant to at least two drugs used for the treatment of TB, and originally is developed when a case of drug-susceptible TB is improperly or incompletely treated. This work is concerned with a mathematical model to evaluate the effect of MDR-TB on TB epidemic and its control. The model assessing the transmission dynamics of both drug-sensitive and drug-resistant TB includes slow TB (cases that result from endogenous reactivation of susceptible and resistant latent infections). We identify the steady states of the model to analyse their stability. We establish threshold conditions for possible scenarios: elimination of sensitive and resistant strains and coexistence of both. We find that the effective reproductive number is composed of two critical values, relative reproductive number for drug-sensitive and drug-resistant strains. Our results imply that the potential for the spreading of the drug-resistant strain should be evaluated within the context of several others factors. We have also found that even the considerably less fit drug-resistant strains can lead to a high MDR-TB incidence, because the treatment is less effective against them.pt
dc.description.abstractDespite the availability of effective treatment, tuberculosis (TB) remains a major global cause of mortality. Multidrug-resistant tuberculosis (MDR-TB) is a form of TB that is resistant to at least two drugs used for the treatment of TB, and originally ispt_BR
dc.relation.ispartofMathematical biosciences and engineeringpt_BR
dc.relation.ispartofabbreviationMBEpt_BR
dc.publisher.citySpringfield, MOpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAmerican Institute of Mathematical Sciences (AIMS)pt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationAug.pt_BR
dc.identifier.citationMathematical Biosciences And Engineering. Amer Inst Mathematical Sciences, v. 11, n. 4, n. 971, n. 993, 2014.pt_BR
dc.language.isoengpt_BR
dc.description.volume11pt_BR
dc.description.issuenumber4pt_BR
dc.description.issuesupplementpt_BR
dc.description.issuespecialpt_BR
dc.description.firstpage971pt_BR
dc.description.lastpage993pt_BR
dc.rightsabertopt_BR
dc.rightsFechadopt_br
dc.sourceWOSpt_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1547-1063pt_BR
dc.identifier.eissn1551-0018pt_BR
dc.identifier.wosidWOS:000332763800013pt_BR
dc.identifier.doi10.3934/rnbe.2014.11.971pt_BR
dc.identifier.urlhttp://www.aimspress.com/article/10.3934/mbe.2014.11.971pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2014-07-30T14:05:54Z
dc.date.available2015-11-26T16:31:25Z-
dc.date.accessioned2014-07-30T14:05:54Z
dc.date.accessioned2015-11-26T16:31:25Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:05:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:31:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57874
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57874-
dc.contributor.departmentDepartamento de Matemática Aplicadapt_BR
dc.contributor.unidadeInstituto de Matemática, Estatística e Computação Científicapt_BR
dc.description.abstractalternativept_BR
dc.subject.keywordMDR-TBpt_BR
dc.subject.keywordDrug resistancept_BR
dc.subject.keywordTreatmentpt_BR
dc.subject.keywordMathematical modelspt_BR
dc.identifier.source000332763800013pt_BR
dc.creator.orcid0000-0002-1711-363Xpt_BR
dc.type.formArtigopt_BR
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