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Type: Artigo de periódico
Title: Molecularly imprinted polymers as analyte sequesters and selective surfaces for easy ambient sonic-spray ionization
Author: Figueiredo, EC
Sanvido, GB
Arruda, MAZ
Eberlin, MN
Abstract: The use of a molecularly imprinted polymer (MIP) as a selective surface for ambient mass spectrometry is demonstrated. The MIP is used to sequester target analytes from urine and easy ambient sonic-spray ionization mass spectrometry (EASI-MS) is shown to be able to efficiently desorb the analytes from the MIP surface and then transfer them in protonated forms to the gas phase for MS analysis. A set of five phenothiazines (chlorpromazine, perphenazine, triflupromazine, thioridazine and prochlorperazine) were chosen from a proof-of-principle class of drug samples. A chlorpromazine-imprinted methacrylic polymer was synthesized and used to prepare a MIP probe. The MIP-EASI-MS technique using acidified methanol as solvent has been shown to allow quantification of all five drugs in urine with LOQ of ca. 1 mu mol L(-1).
Country: Inglaterra
Editor: Royal Soc Chemistry
Citation: Analyst. Royal Soc Chemistry, v. 135, n. 4, n. 726, n. 730, 2010.
Rights: aberto
Identifier DOI: 10.1039/b923289c
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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