Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/57703
Type: Artigo de periódico
Title: Modulation of the severity of experimental autoimmune encephalomyelitis by gamma delta T lymphocytes activated by mycobacterial antigens
Author: Diaz-Bardales, BM
Novaski, SMS
Goes, AE
Castro, GM
Mengel, J
Santos, LMB
Abstract: Immunity to mycobacterial antigens may contribute to the maintenance of self-tolerance. Exposure of the immune system to mycobacterial antigen might well stimulate the immune system to exert control over unwanted self-reactive clones. We demonstrated that in vivo administration of Mycobacterium tuberculosis, PPD, and PPD peptide (180-196) prior to immunization with Myelin Basic Protein (MBP) led to a moderate increase of gamma delta T cells, suppression of the immune response, and reduction in the severity of Experimental Autoimmune Encephalomyelitis. The immunosuppression observed is due, at least in part, to the production of Transforming growth factor-beta (TGF beta) by the gamma delta T lymphocytes.
Subject: EAE
autoimmunity
TGF beta
T TCR gamma delta
mycobacterial antigens
Country: EUA
Editor: Marcel Dekker Inc
Rights: fechado
Identifier DOI: 10.1081/IMM-100105068
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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