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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleModulation of smooth muscle cell function: Morphological evidence for a contractile to synthetic transition in the rat ventral prostate after castrationpt_BR
dc.contributor.authorVilamaior, PSLpt_BR
dc.contributor.authorTaboga, SRpt_BR
dc.contributor.authorCarvalho, HFpt_BR
unicamp.author.emailtaboga@bio.ibilce.unesp.brpt_BR
unicamp.authorUNESP, IBILCE, Dept Biol, Lab Microscopia & Microana, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil UNICAMP, Dept Cell Biol, Campinas, SP, Brazil Univ Ctr Rio Preto, UNIRP, BR-15054000 Sao Jose Do Rio Preto, SP, Brazilpt_BR
dc.subjectandrogen deprivationpt_BR
dc.subjectcastrationpt_BR
dc.subjectsmooth muscle cellpt_BR
dc.subjectrat ventral prostatept_BR
dc.subject.wosEpithelial Interactionspt_BR
dc.subject.wosElectron Microscopypt_BR
dc.subject.wosStromapt_BR
dc.subject.wosExpressionpt_BR
dc.description.abstractIn this study, we evaluated the involvement of rat ventral prostate smooth muscle cells (SMC) in secretory activity and whether this function is modulated after castration. Cell morphology was examined at both light and electron microscopy levels and the organelles involved in secretory function were labeled by the zinc-iodide-osmium (ZIO) method at the ultrastructural level and their volume density was determined by stereology. Castration resulted in marked changes of the SMC, which adopted a spinous aspect and abandoned the layered arrangement observed in the prostates of non-castrated rats. The volume density of ZIO reactive organelles increased progressively after castration, reaching significantly higher levels 21 days after castration, Since previous studies have demonstrated that SMC express SMC markers (even 21 days after castration) and are able to respond to adrenergic stimulation, we concluded that differentiated SMC are able to shift from a predominantly contractile to a more synthetic phenotype without changing their differentiation status. (c) 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.pt
dc.relation.ispartofCell Biology Internationalpt_BR
dc.relation.ispartofabbreviationCell Biol. Int.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherAcademic Press Ltd Elsevier Science Ltdpt_BR
dc.date.issued2005pt_BR
dc.date.monthofcirculationSEPpt_BR
dc.identifier.citationCell Biology International. Academic Press Ltd Elsevier Science Ltd, v. 29, n. 9, n. 809, n. 816, 2005.pt_BR
dc.language.isoenpt_BR
dc.description.volume29pt_BR
dc.description.issuenumber9pt_BR
dc.description.firstpage809pt_BR
dc.description.lastpage816pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESPpt_BR
dc.identifier.issn1065-6995pt_BR
dc.identifier.wosidWOS:000232023600012pt_BR
dc.identifier.doi10.1016/j.cellbi.2005.05.006pt_BR
dc.date.available2014-11-18T16:51:03Z
dc.date.available2015-11-26T16:57:22Z-
dc.date.accessioned2014-11-18T16:51:03Z
dc.date.accessioned2015-11-26T16:57:22Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T16:51:03Z (GMT). No. of bitstreams: 1 WOS000232023600012.pdf: 637698 bytes, checksum: 9ce013986a696591671080089b2cea28 (MD5) Previous issue date: 2005en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:57:22Z (GMT). No. of bitstreams: 2 WOS000232023600012.pdf: 637698 bytes, checksum: 9ce013986a696591671080089b2cea28 (MD5) WOS000232023600012.pdf.txt: 27666 bytes, checksum: 1f3c2ce9336544e9efa7ed24f4a0d5c4 (MD5) Previous issue date: 2005en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57697pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/57697
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57697-
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