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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleModulation of smooth muscle cell function: Morphological evidence for a contractile to synthetic transition in the rat ventral prostate after castrationpt_BR
dc.contributor.authorVilamaior, PSLpt_BR
dc.contributor.authorTaboga, SRpt_BR
dc.contributor.authorCarvalho, HFpt_BR
unicamp.authorUNESP, IBILCE, Dept Biol, Lab Microscopia & Microana, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil UNICAMP, Dept Cell Biol, Campinas, SP, Brazil Univ Ctr Rio Preto, UNIRP, BR-15054000 Sao Jose Do Rio Preto, SP, Brazilpt_BR
dc.subjectandrogen deprivationpt_BR
dc.subjectsmooth muscle cellpt_BR
dc.subjectrat ventral prostatept_BR
dc.subject.wosEpithelial Interactionspt_BR
dc.subject.wosElectron Microscopypt_BR
dc.description.abstractIn this study, we evaluated the involvement of rat ventral prostate smooth muscle cells (SMC) in secretory activity and whether this function is modulated after castration. Cell morphology was examined at both light and electron microscopy levels and the organelles involved in secretory function were labeled by the zinc-iodide-osmium (ZIO) method at the ultrastructural level and their volume density was determined by stereology. Castration resulted in marked changes of the SMC, which adopted a spinous aspect and abandoned the layered arrangement observed in the prostates of non-castrated rats. The volume density of ZIO reactive organelles increased progressively after castration, reaching significantly higher levels 21 days after castration, Since previous studies have demonstrated that SMC express SMC markers (even 21 days after castration) and are able to respond to adrenergic stimulation, we concluded that differentiated SMC are able to shift from a predominantly contractile to a more synthetic phenotype without changing their differentiation status. (c) 2005 International Federation for Cell Biology. Published by Elsevier Ltd. All rights
dc.relation.ispartofCell Biology Internationalpt_BR
dc.relation.ispartofabbreviationCell Biol. Int.pt_BR
dc.publisherAcademic Press Ltd Elsevier Science Ltdpt_BR
dc.identifier.citationCell Biology International. Academic Press Ltd Elsevier Science Ltd, v. 29, n. 9, n. 809, n. 816, 2005.pt_BR
dc.sourceWeb of Sciencept_BR
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