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Type: Artigo de periódico
Title: Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats
Author: Hirata, AE
Alvarez-Rojas, F
Carvalheira, JBC
Carvalho, CRD
Dolnikoff, MS
Saad, MJA
Abstract: PTP1B has been shown to be a negative regulator of the insulin signal transduction in insulin resistant states. Herein we investigated IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of 10 and 28-week-old MSG-insulin resistant rats which represent different stages of insulin resistance. Our results demonstrated that the increase in PTP1B expression and/or association with IR in MSG animals may contribute to the impaired insulin signaling mainly in liver and muscle. Although, adipose tissue of 10-week-old MSG rats showed higher PTP1B expression and IR/PTP1B interaction, they were not sufficient to impair all insulin signaling since IRS-2 phosphorylation and association with PI3-kinase and Akt serine phosphorylation were increased, which may contribute for the increased adiposity of these animals. In 28-week-old-MSG rats there was an increase in IR/PTP1B interaction and reduced insulin signaling in liver, muscle and adipocytes, and a more pronounced insulin resistance. (C) 2003 Elsevier Science Inc. All rights reserved.
Subject: insulin
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/S0024-3205(03)00477-6
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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