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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.typeArtigopt_BR
dc.titleModulation by endogenous prostanoids of the vasoconstrictor activity of endothelin-1 in the canine isolated, perfused spleenpt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorGrassi-Kassisse, D.M.pt_BR
dc.contributor.authorDE Nucci, G.pt_BR
dc.contributor.authorWithrington, P.G.pt_BR
unicamp.authorUNIV LONDON QUEEN MARY & WESTFIELD COLL,FAC BASIC MED SCI,LONDON E1 4NS,ENGLANDpt_BR
dc.subjectDinoprostonapt_BR
dc.subjectIndometacinapt_BR
dc.subjectProstaglandinaspt_BR
dc.subject.otherlanguageDinoprostonept_BR
dc.subject.otherlanguageIndomethacinpt_BR
dc.subject.otherlanguageProstaglandinspt_BR
dc.subject.wosFunctional Expressionpt_BR
dc.subject.wosSmooth-musclept_BR
dc.subject.wosReceptorpt_BR
dc.subject.wosCloningpt_BR
dc.subject.wosPeptidept_BR
dc.subject.wosReleasept_BR
dc.subject.wosCdnapt_BR
dc.subject.wosProstacyclinpt_BR
dc.subject.wosIndomethacinpt_BR
dc.subject.wosEicosanoidspt_BR
dc.description.abstract1 Endothelin-1 (ET-1, 0.4-200 pmol) was injected into the arterial circuit of the isolated perfused spleen of the dog in which splenic arterial perfusion pressure and spleen weight were recorded continuously. 2 Serial collection was made of splenic venous effluent before and after intra-arterial injection of ET-1 and assayed by direct radioimmunoassay for prostaglandin E(2) (PGE(2)), 6-oxo-PGF(1 alpha) and thromboxane B-2 (TXB(2)). 3 ET-1 caused graded arterial vasoconstriction of prolonged duration with small reductions in spleen weight at higher doses. 4 ET-1 cause a dose-related release of PGE(2), 6-oxo-PGF(1 alpha) and TXB(2) into the splenic venous effluent. The mean peak increase above the basal levels following 200 pmol of ET-1 was 800% for PGE(2), 233% for 6-oxo-PGF(1 alpha) and 205% for TXB(2). 5 Intra-arterial infusion of indomethacin significantly reduced the basal release of all three eicosanoids and significantly elevated the basal splenic vascular resistance. The release of all three eicosanoids in response to ET-1 and adrenaline (Ad) was significantly reduced by indomethacin and the accompanying increases in the splenic arterial vascular resistance were significantly potentiated at low doses of ET-1. The splenic arterial vascular responses to Ad were unchanged by indomethacin infusion. 6 These results indicate that the release of eicosanoids may modulate the splenic vascular responses to ET-1pt
dc.relation.ispartofBritish journal of pharmacologypt_BR
dc.relation.ispartofabbreviationBr. j. pharmacol.pt_BR
dc.publisher.cityLondrespt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherBritish Pharmacological Societypt_BR
dc.date.issued1994pt_BR
dc.date.monthofcirculationNov.pt_BR
dc.identifier.citationBritish Journal Of Pharmacology. Stockton Press, v. 113, n. 3, n. 675, n. 680, 1994.pt_BR
dc.language.isoengpt_BR
dc.description.volume113pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage675pt_BR
dc.description.lastpage680pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.sourceWOSpt_br
dc.identifier.issn0007-1188pt_BR
dc.identifier.eissn1476-5381pt_BR
dc.identifier.wosidWOS:A1994PN23700005pt_BR
dc.identifier.doi10.1111/j.1476-5381.1994.tb17045.xpt_BR
dc.identifier.urlhttps://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.1994.tb17045.xpt_BR
dc.description.sponsorshipFAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPESP – FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.date.available2014-12-16T11:37:32Z
dc.date.available2015-11-26T16:26:35Z-
dc.date.accessioned2014-12-16T11:37:32Z
dc.date.accessioned2015-11-26T16:26:35Z-
dc.description.provenanceMade available in DSpace on 2014-12-16T11:37:32Z (GMT). No. of bitstreams: 1 WOSA1994PN23700005.pdf: 1094779 bytes, checksum: 778fc7ab7b957dc50e54dfabff4c8011 (MD5) Previous issue date: 1994en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:26:35Z (GMT). No. of bitstreams: 2 WOSA1994PN23700005.pdf: 1094779 bytes, checksum: 778fc7ab7b957dc50e54dfabff4c8011 (MD5) WOSA1994PN23700005.pdf.txt: 30325 bytes, checksum: a0137255db62a129f9888f63a0cedade (MD5) Previous issue date: 1994en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57678pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/57678
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57678-
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.sourceA1994PN23700005-
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.type.formArtigo original-
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