Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/57634
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCytotoxic, Antitumour and Antimetastatic Activity of Two New Polyacetylenes Isolated from Vernonia scorpioides (Lam.) Perspt_BR
dc.contributor.authorKlein, JBpt_BR
dc.contributor.authorNowill, AEpt_BR
dc.contributor.authorFranchi, GCpt_BR
dc.contributor.authorBiavatti, MWpt_BR
dc.contributor.authorQuintao, NLMpt_BR
dc.contributor.authorde Freitas, RApt_BR
unicamp.author.emailnara.quintao@univali.brpt_BR
unicamp.authorKlein, Juliana B. Quintao, Nara L. M. Univ Vale Itajai, Itajai, SC, Brazilpt_BR
unicamp.authorNowill, Alexandre E. Franchi, Gilberto C., Jr. State Univ Campinas UNICAMP, Fac Med Sci, Oncohematol Child Res Ctr, Campinas, SP, Brazilpt_BR
unicamp.authorBiavatti, Maique W. Univ Fed Santa Catarina, Dept Pharmaceut Sci, Florianopolis, SC, Brazilpt_BR
unicamp.authorde Freitas, Rilton A. Univ Fed Parana, Dept Chem, BR-80060000 Curitiba, Parana, Brazilpt_BR
dc.subject.wosEchinacea-pallidapt_BR
dc.subject.wosNatural-productspt_BR
dc.subject.wosPaclitaxelpt_BR
dc.subject.wosCellspt_BR
dc.subject.wosGrowthpt_BR
dc.subject.wosDrugspt_BR
dc.subject.wosAssaypt_BR
dc.subject.wosStimulationpt_BR
dc.subject.wosInductionpt_BR
dc.subject.wosEfficacypt_BR
dc.description.abstractVernonia scorpioides (Lam.) Pers., popularly known as Enxuga, Erva-de-SAo SimAo and Piraca, has been used in folk medicine for its anti-inflammatory, wound healing and antimicrobial properties. Two polyacetylenes, 5-octa-2,4,6-triynyl-furan-2(5H)-one (1) and 8-hydroxy 3-4 dihydrovernoniyne (2), were isolated from the dichloromethane extract fraction of V.scorpioides. In this study, polyacetylene 1 demonstrated a more potent cytotoxic activity than 2 in the tumour cell lines examined, and cytotoxicity was found to be comparable to a commercial drug (p>0.05) in melanoma cells. No significant cytotoxic effect was observed in normal cell lines. Furthermore, polyacetylene 1 induced an in vitro increase in caspase-3 activity in B16F10 cells. When polyacetylene 1 was administered intraperitoneally (i.p.) in mice, a reduction in solid tumour volume and metastasis was observed in mice injected with B16F10 cells. An increase in locomotor activity was also observed in mice with solid tumours, and an inhibition of mechanical hypersensitivity was observed in a mouse model of metastasis. Notably, no significant morphological change was observed in several organs harvested from the treated mice. In conclusion, in vitro and in vivo anticancer activity of polyacetylene 1 was consistently observed and involved the induction of apoptosis by the activation of caspase-3. The anticancer activity demonstrated by polyacetylene 1, together with the absence of preliminary toxicological effects, represents a new and interesting option for the management of neoplastic disease.pt
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologypt_BR
dc.relation.ispartofabbreviationBasic Clin. Pharmacol. Toxicol.pt_BR
dc.publisher.cityHobokenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationBasic & Clinical Pharmacology & Toxicology. Wiley-blackwell, v. 113, n. 5, n. 307, n. 315, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume113pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage307pt_BR
dc.description.lastpage315pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1742-7835pt_BR
dc.identifier.eissn1742-7843pt_BR
dc.identifier.wosidWOS:000325465200004pt_BR
dc.identifier.doi10.1111/bcpt.12098pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundacao de Apoio a Pesquisa Cientofica e Tecnologica do Estado de Santa Catarina (FAPESC)pt_BR
dc.description.sponsorshipPro-Reitoria de Pesquisa, Pos-Graduacao, Extensao e Cultura of the Universidade do Vale do Itajai (ProP-PEC/UNIVALI), Brazilpt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-07-30T14:03:23Z
dc.date.available2015-11-26T16:43:43Z-
dc.date.accessioned2014-07-30T14:03:23Z
dc.date.accessioned2015-11-26T16:43:43Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:03:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:43:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57634
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57634-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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