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|Type:||Artigo de periódico|
|Title:||CYTOTOXIC DERIVATIVES OF WITHANOLIDES ISOLATED FROM THE LEAVES OF Acnistus arborescens.|
|Abstract:||CYTOTOXIC DERIVATIVES OF WITHANOLIDES ISOLATED FROM THE LEAVES OF Acnistus arborescens.. In view of anticancer activity of 7 beta-acetoxywithanolide D (2) and 7 beta-16 alpha-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer activity of these derivatives was evaluated in a panel of cancer cell lines: human breast (BC-1), human lung (Lu1), human colon (Col2) and human oral epidermoid carcinoma (KB). Compounds 2a (acetylation of 2), 3b (oxidation of 3) and 2c (hydrogenation of 2) exhibited the highest anticancer activity against human lung cancer cells, with ED(50) values of 0.19, 0.25 and 0.63 mu g/mL, respectively.|
human lung cancer
|Editor:||Soc Brasileira Quimica|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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