Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/57627
Type: Artigo de periódico
Title: CYTOTOXIC DERIVATIVES OF WITHANOLIDES ISOLATED FROM THE LEAVES OF Acnistus arborescens.
Author: Minguzzi, S
Barata, LES
Cordell, GA
Abstract: CYTOTOXIC DERIVATIVES OF WITHANOLIDES ISOLATED FROM THE LEAVES OF Acnistus arborescens.. In view of anticancer activity of 7 beta-acetoxywithanolide D (2) and 7 beta-16 alpha-diacetoxywithonide D (3), isolated from the leaves of Acnistus arborescens (Solanaceae), five withanolide derivatives were obtained and their structures were determined by NMR, MS and IV data analysis. The in vitro anticancer activity of these derivatives was evaluated in a panel of cancer cell lines: human breast (BC-1), human lung (Lu1), human colon (Col2) and human oral epidermoid carcinoma (KB). Compounds 2a (acetylation of 2), 3b (oxidation of 3) and 2c (hydrogenation of 2) exhibited the highest anticancer activity against human lung cancer cells, with ED(50) values of 0.19, 0.25 and 0.63 mu g/mL, respectively.
Subject: Acnistus arborescens
withanolides derivatives
human lung cancer
Country: Brasil
Editor: Soc Brasileira Quimica
Rights: aberto
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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