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Type: Artigo de periódico
Title: Cytotoxic activity of Guettarda pohliana Mull. Arg. (Rubiaceae)
Author: de Oliveira, PRN
Testa, G
Medina, RP
de Oliveira, CMA
Kato, L
da Silva, CC
de Carvalho, JE
Santin, SMO
Abstract: The cytotoxic activity of crude extracts and their fractions from leaves and roots of G. pohliana was assessed against nine human cancer cell lines: melanoma (UACC-62), breast (MCF-7), breast expressing the multidrug resistance phenotype (NCI-ADR), lung (NCI-460), prostate (PCO-3), kidney (786-0), ovarian (OVCAR), colon (HT-29) and leukaemia (K-562). The hexane fraction from leaves (HL) and ethyl acetate (EAR), chloroform (CR) and hydromethanolic (HMR) fractions from roots were the most active fractions against K-562 with GI(50) values being lower than 1gmL(-1). Also, CR and HMR fractions were active against UACC-62 cell line in the same order of magnitude. The phytochemical study of the CR fraction allowed identifying the known iridoids secoxyloganin, sweroside and loganin.
Subject: Guettarda pohliana
cytotoxic activity
cancer cell lines
Country: Inglaterra
Editor: Taylor & Francis Ltd
Citation: Natural Product Research. Taylor & Francis Ltd, v. 27, n. 18, n. 1677, n. 1681, 2013.
Rights: fechado
Identifier DOI: 10.1080/14786419.2012.761616
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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