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|Type:||Artigo de periódico|
|Title:||Cytotoxic activity of Guettarda pohliana Mull. Arg. (Rubiaceae)|
|Author:||de Oliveira, PRN|
de Oliveira, CMA
da Silva, CC
de Carvalho, JE
|Abstract:||The cytotoxic activity of crude extracts and their fractions from leaves and roots of G. pohliana was assessed against nine human cancer cell lines: melanoma (UACC-62), breast (MCF-7), breast expressing the multidrug resistance phenotype (NCI-ADR), lung (NCI-460), prostate (PCO-3), kidney (786-0), ovarian (OVCAR), colon (HT-29) and leukaemia (K-562). The hexane fraction from leaves (HL) and ethyl acetate (EAR), chloroform (CR) and hydromethanolic (HMR) fractions from roots were the most active fractions against K-562 with GI(50) values being lower than 1gmL(-1). Also, CR and HMR fractions were active against UACC-62 cell line in the same order of magnitude. The phytochemical study of the CR fraction allowed identifying the known iridoids secoxyloganin, sweroside and loganin.|
cancer cell lines
|Editor:||Taylor & Francis Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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