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Type: Artigo de periódico
Title: Cytotoxic activity of (S)-goniothalamin and analogues against human cancer cells
Author: de Fatima, A
Kohn, LK
de Carvalho, JE
Pilli, RA
Abstract: (R)- and (S)-Goniothalamin (1) and analogues 2-9 were efficiently prepared in high overall yield and enantiomeric purity, and their cytotoxic activities were evaluated against eight human cancer cell lines. A structure-activity relationship study (SAR) allowed us to establish the relevant structural features for the cytotoxic activity of goniothalamin analogues. In addition, we have identified non-natural form of goniothalamin (S)-1 and analogue 5 as the highest and more selective cytotoxic compounds against kidney cancer cell growth (786-0) with IC50 = 4 and 5 nM, respectively, and compound 8 (IC50 = 4 nM) as the more potent against breast cancer cells with resistance phenotype for adryamycin (c) 2005 Elsevier Ltd. All rights reserved.
Subject: (R)- and (S)-goniothalamin
styryl lactones
cytotoxic activity
cancer cell lines
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Bioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 14, n. 3, n. 622, n. 631, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2005.08.036
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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