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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCytomorphological Criteria, Subclassifications of Endocervical Glandular Cell Abnormalities, and Histopathological Outcome: A Frequency Studypt_BR
dc.contributor.authorDalla Nora, LCpt_BR
dc.contributor.authorAzara, CZSpt_BR
dc.contributor.authorPace, ELDpt_BR
dc.contributor.authorMartins, CMpt_BR
dc.contributor.authorZeferino, LCpt_BR
dc.contributor.authorWestin, MCDpt_BR
dc.contributor.authorDerchain, SFpt_BR
dc.contributor.authorRabelo-Santos, SHpt_BR
unicamp.authorRabelo-Santos, Silvia Helena Univ Fed Goias, Fac Farm, Sch Pharm, BR-74605220 Goiania, Go, Brazilpt_BR
unicamp.authorZeferino, Luiz Carlos do Amaral Westin, Maria Cristina Derchain, Sophie Francoise Univ Estadual Campinas, Dept Obstet & Gynecol, Sao Paulo, Brazilpt_BR
dc.subjectcytomorphological criteriapt_BR
dc.subjectatypical glandular cellspt_BR
dc.subjectadenocarcinoma in situpt_BR
dc.subjectcervical smearpt_BR
dc.subject.wosUndetermined Significance Aguspt_BR
dc.subject.wosBethesda 2001 Classificationpt_BR
dc.subject.wosAdenocarcinoma In-situpt_BR
dc.subject.wosPapanicolaou Smearspt_BR
dc.description.abstractThe objective of this study was to evaluate the frequency and the significance of cytomorphological criteria defined in studies as being predictive of neoplasia in cervical smears of women with a cytological diagnosis of atypical glandular cells (AGC) or adenocarcinoma in situ (AIS). Women (n = 103) with cytological findings suggestive of AGC or AIS, whose diagnoses were later established by histopathology, were included in the study. The criteria analyzed and classified as present or absent in cervical smears previously classified as AGC-NOS (not otherwise specified), AGC-FN (favor neoplasia), or AIS were as follows: irregular nuclear membranes; scanty cytoplasm; dyskeratotic cells; increased nuclear/cytoplasmic ratio; nucleoli; overlapping; papillary clusters, feathering; loss of polarity; nuclear enlargement; coarsely granular chromatin; and pseudostratified strips. Histopathology resulted in neoplastic diagnoses in 55 cases (53.3%) and nonneoplastic diagnoses in 48 cases (46.6%). Coarsely granular chromatin was observed in 62.5% of cases with a diagnosis of neoplasia. Feathering was present in 80% of cases of histopathological AIS. Loss of polarity and coarsely granular chromatin were significantly associated with neoplastic diagnosis considering all subcategories of glandular abnormalities diagnosis. In AGC-SOE subclassification. coarsely granular chromatin was significantly associated with neoplastic diagnosis. The presence of nucleoli was significantly associated with neoplastic diagnosis in cervical smears qualified as AGC-FN and AIS. Nuclear enlargement, increased nuclear/cytoplasmic ratio, coarsely granular chromatin and overlapping cells were found in all the subclassifications of glandular cell abnormalities irrespective of the histopathological results. Chromatin aspects, polarity, and presence of nucleoli can predict neoplasia. Diagn. Cytopathol. 2010;38:806-810. (C) 2010 Wiley-Liss,
dc.relation.ispartofDiagnostic Cytopathologypt_BR
dc.relation.ispartofabbreviationDiagn. Cytopathol.pt_BR
dc.identifier.citationDiagnostic Cytopathology. Wiley-liss, v. 38, n. 11, n. 806, n. 810, 2010.pt_BR
dc.sourceWeb of Sciencept_BR
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