Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/57555
Type: Artigo de periódico
Title: Cyclosporin A inhibits production and activity of matrix metalloproteinases by gingival fibroblasts
Author: Bolzani, G
Della Coletta, R
Junior, HM
de Almeida, OP
Graner, E
Abstract: Cyclosporin A (CyA) is a potent immunosuppressor used in organ transplantation and in the management of various autoimmune diseases. Gingival overgrowth is one of the side-effects of the CyA-treatment, affecting the attached gingiva of 25-81% of treated patients. To investigate the production and activity of matrix metalloproteinases (MMPs) in the CyA-induced gingival overgrowth, 2 well-documented models were utilized: the in vivo CyA-induced rat gingival overgrowth and primary cultures of human gingival fibroblasts treated with CyA. Our results obtained from the Western blot assays demonstrated clearly that the production of MMP-1 and MMP-3 was significantly inhibited by CyA at similar concentrations found in the serum of patients undergoing CyA-treatment. Moreover, the gelatinolytic activity of MMP-2 was also reduced both in cultured fibroblasts and in the rat CyA-induced gingival overgrowth. Taken together, the data presented here suggest that these inhibitory effects may contribute to the extracellular matrix (ECM) components accumulation in the CyA-induced gingival overgrowth.
Subject: cyclosporin A
matrix metalloproteinases
extracellular matrix
gingival overgrowth
Country: Dinamarca
Editor: Munksgaard Int Publ Ltd
Rights: fechado
Identifier DOI: 10.1034/j.1600-0765.2000.035001051.x
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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