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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCyclosporin A inhibits calcium uptake by Citrus sinensis mitochondriapt_BR
dc.contributor.authorde Oliveira, HCpt_BR
dc.contributor.authorSaviani, EEpt_BR
dc.contributor.authorde Oliveira, JFPpt_BR
dc.contributor.authorSalgado, Ipt_BR
unicamp.author.emailionesm@unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Inst Biol, Dept Bioquim, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectcalcium transportpt_BR
dc.subjectcyclosporin Apt_BR
dc.subjectplant mitochondriapt_BR
dc.subjectcultured Citrus sinensis cellspt_BR
dc.subject.wosPermeability Transition Porept_BR
dc.subject.wosProgrammed Cell-deathpt_BR
dc.subject.wosRat-liver Mitochondriapt_BR
dc.subject.wosCorn Mitochondriapt_BR
dc.subject.wosTransportpt_BR
dc.subject.wosReleasept_BR
dc.subject.wosBindingpt_BR
dc.subject.wosPlantspt_BR
dc.subject.wosProbept_BR
dc.subject.wosCa-2pt_BR
dc.description.abstractCyclosporin A (CsA) is a well-known inhibitor of prooxidant-induced mitochondrial Ca2+ release and apoptosis in mammalian cells. CsA also protects plants against programmed cell death by an unknown mechanism. In this study, we examined the effects of CsA on Ca2+ transport by mitochondria isolated from cultured Citrus sinensis Obs. cv. Pera cells. CsA inhibited Ca2+ uptake by Citrus mitochondria in a concentration-dependent manner, but did not affect ruthenium red-induced Ca2+ release. CsA also prevented the decrease in mitochondrial membrane potential and the uncoupling of respiratory activity resulting from Ca2+ uptake. As expected, CsA did not affect Ca2+ influx in rat liver mitochondria. These results indicate a difference in the Ca2+ transport systems of plant and animal mitochondria. The inhibitory action of CsA on Ca2+ uptake by Citrus mitochondria could explain the ability of this drug to prevent plant programmed cell death, a process that can be triggered by mitochondrial Ca2+ loading. (c) 2006 Elsevier Ireland Ltd. All rights reserved.pt
dc.relation.ispartofPlant Sciencept_BR
dc.relation.ispartofabbreviationPlant Sci.pt_BR
dc.publisher.cityClarept_BR
dc.publisher.countryIrlandapt_BR
dc.publisherElsevier Ireland Ltdpt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationPlant Science. Elsevier Ireland Ltd, v. 172, n. 3, n. 665, n. 670, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume172pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage665pt_BR
dc.description.lastpage670pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0168-9452pt_BR
dc.identifier.wosidWOS:000244358700028pt_BR
dc.identifier.doi10.1016/j.plantsci.2006.12.002pt_BR
dc.date.available2014-11-18T11:17:55Z
dc.date.available2015-11-26T16:54:22Z-
dc.date.accessioned2014-11-18T11:17:55Z
dc.date.accessioned2015-11-26T16:54:22Z-
dc.description.provenanceMade available in DSpace on 2014-11-18T11:17:55Z (GMT). No. of bitstreams: 1 WOS000244358700028.pdf: 208444 bytes, checksum: e49d4b5c704d2e1f81dfe4b754e72052 (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:54:22Z (GMT). No. of bitstreams: 2 WOS000244358700028.pdf: 208444 bytes, checksum: e49d4b5c704d2e1f81dfe4b754e72052 (MD5) WOS000244358700028.pdf.txt: 27086 bytes, checksum: c599b624b60e148f45896bf5b45b2795 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57554pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/57554
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57554-
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