Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/57531
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.contributor.authorunicampLonghini, Ana Leda Figueiredopt_BR
dc.contributor.authorunicampCampos, Paula de Melopt_BR
dc.contributor.authorunicampSaad, Sara Teresinha Olallapt_BR
dc.typeOutros documentospt_BR
dc.titleCXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates cxcr4 response to cxcl12pt_BR
dc.contributor.authorMelo, R.D.C.pt_BR
dc.contributor.authorCampos, P.D.pt_BR
dc.contributor.authorFavaro, P.pt_BR
dc.contributor.authorBigarella, C.L.pt_BR
dc.contributor.authorBaratti, M.O.pt_BR
dc.contributor.authorLonghini, A.L.pt_BR
dc.contributor.authorTraina, F.pt_BR
dc.contributor.authorSaad, S.T.O.pt_BR
dc.subjectLeucemiapt_BR
dc.subject.otherlanguageLeukemiapt_BR
dc.description.abstractRecently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In this study, we aimed to investigate the expression of CXCR7 in leukemic cells, as well as its participation in CXCL12 response. Interesting, we clearly demonstrated that CXCR7 is highly expressed in acute lymphoid leukemic cells compared with myeloid or normal hematopoietic cells and that CXCR7 contributed to T-acute lymphoid leukemic cell migration induced by CXCL12. Moreover, we showed that the cellular location of CXCR7 varied among T-lymphoid cells and this finding may be related to their migration capacity. Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells.pt
dc.description.abstractRecently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In thipt_BR
dc.relation.ispartofPLoS onept_BR
dc.publisher.citySan Francisco, CApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherPublic Library of Sciencept_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationJan.pt_BR
dc.identifier.citationPlos One. Public Library Science, v. 9, n. 1, 2014.pt_BR
dc.language.isoengpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage1pt_BR
dc.description.lastpage12pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1932-6203pt_BR
dc.identifier.doi10.1371/journal.pone.0085926pt_BR
dc.identifier.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085926pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2014-07-30T14:03:12Z
dc.date.available2015-11-26T16:43:04Z-
dc.date.accessioned2014-07-30T14:03:12Z
dc.date.accessioned2015-11-26T16:43:04Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:03:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2021-04-06T19:47:21Z : No. of bitstreams: 1 000330621900012.pdf: 1931104 bytes, checksum: 1cadfc4b5c7a466707ef4dd1dfab5bb7 (MD5)en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:43:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57531
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57531-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000330621900012pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-0809-8068pt_BR
dc.type.formErratapt_BR
dc.identifier.articleid31pt_BR
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000330621900012.pdf1.89 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.