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|Type:||Artigo de periódico|
|Title:||Cr-51-EDTA measurements of the glomerular filtration rate in patients with sickle cell anaemia and minor renal damage|
|Abstract:||Background Creatinine clearance has been reported to be inaccurate for the estimation of glomerular filtration rate (GFR) in patients with sickle cell anaemia (SCA). Inulin clearance, the reference method for GFR estimation, is impractical for routine use in these patients, and Cr-51-EDTA measurements of the GFR have been rarely reported in this disease. Methods In order to obtain reference Cr-51-EDTA values in this disease, we studied 70 patients (40 females; 13-59 years of age, mean: 31.6 years) with homozygous SCA, normal serum creatinine and urinary albumin excretion <or=200 mu g.min(-1). All patients were submitted to single-injection Cr-51-EDTA GFR, urinary albumin and haematocrit measurements. Cr-51-EDTA clearances were calculated in different age groups (<20, 20-29, 30-39, 40-49 and>50 years). Results The mean GFR (+/- standard deviation) obtained for the 70 patients was 111.5 +/- 23.1 ml.min(-1). Analysis of variance for evaluation of the possible interaction effect between Cr-51-EDTA clearance and sex, age, urinary albumin and haematocrit demonstrated patient age as the only factor influencing Cr-51-EDTA clearance (P<0.001). The Spearman correlation coefficient showed a significant relationship between Cr-51-EDTA clearance and patient age (r= - 0.44, P= 0.0001), but not between Cr-51-EDTA and urinary albumin (r= - 0.17, P= 0.1546) or haematocrit (r=0.079, P=0.5121). The group aged 20-29 years presented the highest Cr-51-EDTA clearance mean value (126.7 +/- 20.4 ml.min(-1)), with a progressive reduction in the older groups. Conclusion Young adults with homozygous SCA, normal serum creatinine and micro-albuminuria or normo-albuminuria present supranormal Cr-51-EDTA GFR values. These values rapidly decrease after 30 years of age. We did not find association between urinary albumin and GFR in these patients.|
glomerular filtration rate
sickle cell anaemia
|Editor:||Lippincott Williams & Wilkins|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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