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Type: Artigo de periódico
Title: Costimulatory molecule expression on leukocytes from mice with experimental autoimmune encephalomyelitis treated with IFN-beta
Author: Hallal, DEM
Farias, AS
Oliveira, EC
Diaz-Bardales, BM
Brandao, CO
Protti, GG
Pereira, FG
Metze, IL
Santos, LMB
Abstract: Interferon-beta (IFN-beta) is of benefit in the treatment of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), but the mechanisms by which it exerts this beneficial effect remain uncertain. The present data demonstrate that IFN-beta therapy impairs the proliferative response to concanavalin A (ConA) and myelin basic protein (MBP), decreases expression of the CD80 molecule on leukocytes of treated mice, and may thereby impede the Th1 cell activation-promoting anergy in EAE. Moreover, IFN-beta therapy increases expression of the CTLA4 molecule, which induces a counterregulatory Th2 response. The reduction of CD80 expression with concomitant increase of CTLA4 expression alters the course of EAE and may be useful as a monitor in therapy with IFN-beta.
Country: EUA
Editor: Mary Ann Liebert Inc Publ
Citation: Journal Of Interferon And Cytokine Research. Mary Ann Liebert Inc Publ, v. 23, n. 6, n. 293, n. 298, 2003.
Rights: aberto
Identifier DOI: 10.1089/107999003766628133
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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