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Type: Artigo de periódico
Title: Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation
Author: Tambeli, CH
Young, A
Levine, JD
Gear, RW
Abstract: We evaluated the role of spinal glutamate and substance P receptors in noxious stimulus-induced antinociception (NSIA). NSIA was produced by subdermal capsaicin administration in the hind paw of the rat and measured as attenuation of the jaw-opening reflex. NSIA was completely blocked by spinal intrathecal administration of the selective NMDA receptor antagonist LY235959 as well as the mGluR(5) antagonists MPEP and SIB-1757 and partially attenuated by the selective AMPA/kainate receptor antagonist NBQX; however, neither the mGluR(1) receptor antagonist LY367385 nor the NK1 antagonist L-703,606 affected NSIA. These results suggest that NSIA depends on glutamate. released from the central terminals of the primary afferent nociceptors, acting primarily on NMDA and mGluR(5) receptors. Although substance P is also known to be released by similar stimuli, NK1 receptors do not appear to play a role in NSIA. The implications of these findings in the context of a proposed spinal circuit that mediates NSIA are discussed. (C) 2003 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
Subject: glutamate
noxious stimulus-induced antinociception
NMDA and mGluR(5) receptors
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/S0304-3959(03)00332-4
Date Issue: 2003
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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