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Type: Artigo de periódico
Title: Microbiological changes with the use of locally delivered doxycycline in the periodontal treatment of smokers
Author: Machion, L
Andia, DC
Saito, D
Klein, MI
Goncalves, RB
Casati, MZ
Nociti, FH
Sallum, EA
Abstract: Background: The aim of this study was to evaluate the effect of the association of locally delivered doxycycline 10% and scaling and root planing in the subgingival plaque of smokers. Methods: Sixteen smokers with chronic periodontitis and a minimum of four pockets ( greater than or equal to 5 mm) on anterior teeth that bled on probing were selected. Patients were randomly assigned to one of the following groups: scaling and root planing (SRP) or scaling and root planing followed by local application of doxycycline (SRP-D). Subgingival plaque samples were collected from initially moderate (5 to 6 mm) and deep (greater than or equal to 7 mm) pockets at baseline and 3 months. Polymerase chain reaction (PCR) analysis was used to detect the frequency of Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingiualis (Pg), and Tannerella forsythensis (Tf). Results: No statistically significant difference was found in the reduction of Aa in either the SRP-D or SRP group (P > 0.05). The reduction in Tf, Pg, and Tf + Pg was statistically significant for SRP-D only (P = 0.016, 0.027, and 0.027, respectively). The proportion of sites free of Tf at 3 months was 53% for SRP-D and 9% for SRP (P = 0.02). For Pg, this proportion was 82% and 40%, respectively (P = 0.05). Conclusion: The use of locally delivered doxycycline may promote the elimination of T forsythensis and P gingivalis in a greater proportion of sites compared to conventional scaling and root planing in smokers.
Subject: bacteroides forsythus
comparison studies
doxycycline/therapeutic use
Porphyromonas gingivalis
smoking/adverse effects
Tannerella forsythensis
Country: EUA
Editor: Amer Acad Periodontology
Rights: fechado
Identifier DOI: 10.1902/jop.2004.75.12.1600
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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