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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCompeting-Risks Regression Models in Analysis of Biomarkers as Predictors of High-risk Human Papillomavirus (HPV) Infection Outcomes and Incident CIN in the LAMS Cohortpt_BR
dc.contributor.authorSyrjanen, Spt_BR
dc.contributor.authorLonghato, Apt_BR
dc.contributor.authorSarian, LOpt_BR
dc.contributor.authorNaud, Ppt_BR
dc.contributor.authorDerchain, Spt_BR
dc.contributor.authorRottelli-Martins, Cpt_BR
dc.contributor.authorTatti, Spt_BR
dc.contributor.authorBranca, Mpt_BR
dc.contributor.authorErzen, Mpt_BR
dc.contributor.authorHammes, LSpt_BR
dc.contributor.authorMatos, Jpt_BR
dc.contributor.authorGontijo, Rpt_BR
dc.contributor.authorBraganca, Jpt_BR
dc.contributor.authorArlindo, FCpt_BR
dc.contributor.authorMaeda, MYSpt_BR
dc.contributor.authorCosta, Spt_BR
dc.contributor.authorSyrjanen, Kpt_BR
unicamp.author.emailkari.syrjanen@tyks.fipt_BR
unicamp.authorSyrjanen, Stina Univ Turku, Dept Oral Pathol, Inst Dent, SF-20500 Turku, Finlandpt_BR
unicamp.authorSyrjanen, Kari Turku Univ Hosp, Dept Radiotherapy & Oncol, FIN-20521 Turku, Finlandpt_BR
unicamp.authorLonghato-Filho, Adhemar Univ Sao Paulo, Fac Med, Dept Pathol, Lab Med Invest LIM14, BR-05508 Sao Paulo, Brazilpt_BR
unicamp.authorSarian, Luis O. Derchain, Sophie Gontijo, Renata Braganca, Joana Univ Estadual Campinas, Campinas, SP, Brazilpt_BR
unicamp.authorNaud, Paulo Matos, Jean Arlindo, Francisco C. Hosp Clin Porto Alegre, Porto Alegre, RS, Brazilpt_BR
unicamp.authorLonghato-Filho, Adhemar Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst, Braga, Portugalpt_BR
unicamp.authorTatti, Silvio First Chair Gynecol Hosp Clin, Buenos Aires, DF, Argentinapt_BR
unicamp.authorBranca, Margherita Natl Inst Hlth, Natl Ctr Epidemiol Surveillance & Promot Hlth, Unit Cytopathol, Rome, Italypt_BR
unicamp.authorCosta, Silvano St Orsola Marcello Malpighi Hosp, Dept Obstet & Gynecol, Bologna, Italypt_BR
unicamp.authorErzen, Mojca SIZE Diagnost Ctr, Ljubljana, Sloveniapt_BR
unicamp.authorHammes, Luciano S. Hosp Moinhos Vento, Inst Educ & Res, Porto Alegre, RS, Brazilpt_BR
dc.subjectHigh-risk HPVpt_BR
dc.subjectIncident CINpt_BR
dc.subjectViral outcomespt_BR
dc.subjectLipocalinpt_BR
dc.subjectPAI-2 (Serpin-B2)pt_BR
dc.subjectp300pt_BR
dc.subjectIL-10pt_BR
dc.subjectStratifin (14-3-3)pt_BR
dc.subjectCompeting-risks regressionpt_BR
dc.subjectPredictorspt_BR
dc.subjectLongitudinal settingpt_BR
dc.subject.wosCervical Intraepithelial Neoplasiapt_BR
dc.subject.wosLow-resource Settingspt_BR
dc.subject.wosFormer Soviet-unionpt_BR
dc.subject.wosLatin-americapt_BR
dc.subject.wosUp-regulationpt_BR
dc.subject.wosBase-linept_BR
dc.subject.wosMolecular Markerspt_BR
dc.subject.wosScreening Toolspt_BR
dc.subject.wosIndependent Statespt_BR
dc.subject.wosVisual Inspectionpt_BR
dc.description.abstractTo assess the prediction potential of a 5-biomarker panel for detecting high-risk human papillomavirus (HR-HPV) infections and/or cervical intraepithelial neoplasia (CIN) progression. Five biomarkers, lipocalin, plasminogen activator inhibitor-2, p300, interleukin-10, and stratifin, were assessed in cervical biopsies from 225 women of the Latin American Screening Study. Competing-risks regression models were constructed to assess their predictive power for (i) HR-HPV outcomes (negative, transient, or persistent infection) and (ii) CIN outcomes (no progression, incident CIN1, CIN2, or CIN3). p300, LCN2, stratifin were significantly associated with prevalent HR-HPV but lost their significance in multivariate analysis. In the multivariate model, only p300 was an independent predictor of CIN3 (odds ratio=2.63; 95% confidence interval, 1.05-6.61; P=0.039). In univariate competing-risks regression, lipocalin predicted permanent HR-HPV-negative status, but in the multivariate model, IL-10 emerged as a independent predictor of HPV-negative status (subhazard ratio=4.04; 95% confidence interval, 1.81-9.01; P=0.001). The clinical value of the panel in predicting longitudinal outcomes of HR-HPV infection and/or incident CIN is limited.pt
dc.relation.ispartofInternational Journal Of Gynecological Pathologypt_BR
dc.relation.ispartofabbreviationInt. J. Gynecol. Pathol.pt_BR
dc.publisher.cityPhiladelphiapt_BR
dc.publisher.countryEUApt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationInternational Journal Of Gynecological Pathology. Lippincott Williams & Wilkins, v. 32, n. 4, n. 406, n. 415, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume32pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage406pt_BR
dc.description.lastpage415pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0277-1691pt_BR
dc.identifier.wosidWOS:000323216700010pt_BR
dc.identifier.doi10.1097/PGP.0b013e31826739b1pt_BR
dc.description.sponsorshipEuropean Commission, INCO-DEV Programme [ICA4-CT-2001-10013]pt_BR
dc.description.sponsordocumentnumberEuropean Commission, INCO-DEV Programme [ICA4-CT-2001-10013]pt
dc.date.available2014-07-30T14:00:20Z
dc.date.available2015-11-26T17:48:35Z-
dc.date.accessioned2014-07-30T14:00:20Z
dc.date.accessioned2015-11-26T17:48:35Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:00:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:48:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56331
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56331-
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