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Type: Artigo de periódico
Title: Compatibility and stability of valsartan in a solid pharmaceutical formulation
Author: Julio, TA
Zamara, IF
Garcia, JS
Trevisan, MG
Abstract: Valsartan (VAL) is a highly selective blocker of the angiotensin II receptor that has been widely used in the treatment of hypertension. Active pharmaceutical ingredient compatibility with excipients (crospovidone, hypromellose, magnesium stearate, microcrystalline cellulose and titanium dioxide) is usually evaluated in solid pharmaceutical development. Compatibility and stability can be evaluated by liquid chromatography. Studies were performed using binary mixtures of 1: 1 (w/w) VAL/excipient; samples were stored under accelerated stability test conditions (40 degrees C at 75% relative humidity). The results indicate that VAL is incompatible with crospovidone and hypromellose, which reduced the VAL content and gave rise to new peaks in the chromatogram due to degradation products.
Subject: Valsartan/compatibility
Differential Scanning Calorimetry/drug analysis
High performance liquid chromatography/quantitative analysis Pharmaceutical formulations/quantitative analysis
Country: Brasil
Editor: Univ Sao Paulo, Conjunto Quimicas
Rights: aberto
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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