Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/56287
Type: Artigo de periódico
Title: COMPARISON OF THE ANTIVIRAL ACTIVITY AND TOXICITY OF A PROTEIN MAGNESIUM AMMONIUM PHOSPHOLINOLEATE ANHYDRIDE POLYMER WITH OTHER ANTIVIRAL DRUGS
Author: DURAN, N
HAUN, M
PEREIRADASILVA, L
PISANI, R
PISANI, FJC
SOUZABRITO, ARM
MAZETTO, MN
DASILVANUNES, O
Abstract: 1. SB-73, a magnesium ammonium phospholinoleate anhydride aggregate, exhibited antiviral action in vitro in the concentration range of 50 to 100 mu-g/ml against herpes simplex type 1, stomatitis vesicular virus, adenovirus type 5, and in vivo in the dose range of 0.7 to 1.3 mg/kg against canine parvovirus and distemper virus. 2. The lethal dose (LD50) was 2.71 +/- 1.55 g/kg body weight in mice inoculated intraperitoneally. Oral ingestion of the aggregate up to 30 g/kg body weight by mice had no lethal effects during the 14 days of observation. 3. In in vitro cytotoxicity experiments with fibroblasts (V-79 Chinese hamster cell line), no toxic effects were observed with SB-73 concentrations (120-mu-g/ml) having antiviral activity. 4. In a cellular proliferation experiment using hamster V-79 cells, we observed 72% proliferation after treatment of the cells with a high concentration (500-mu-g/ml) of SB-73. 5. Compound SB-73 showed no genotoxicity for human lymphocytes at concentrations of 100-mu-g/ml. 6. When the cytotoxicity and genotoxicity of SB-73 were compared with those of acyclovir, idoxuridine and AZT at 500 mu-g/ml concentrations the compound was found to have effects similar to those of acyclovir.
Subject: ANTIVIRAL ACTIVITY
POLYPHOSPHATE
MAGNESIUM IONS
ACYCLOVIR
IDOXURIDINE
AZT
HERPES VIRUS
ADENOVIRUS
STOMATITIS VESICULAR VIRUS
PARVOVIRUS
DISTEMPER VIRUS
Country: Brasil
Editor: Assoc Bras Divulg Cientifica
Rights: aberto
Date Issue: 1990
Appears in Collections:Unicamp - Artigos e Outros Documentos

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