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Type: Artigo de periódico
Title: Comparative metabolic profiling of paediatric ependymoma, medulloblastoma and pilocytic astrocytoma
Author: Cuellar-Baena, S
Morales, JM
Martinetto, H
Calvar, J
Sevlever, G
Castellano, G
Cerda-Nicolas, M
Celda, B
Monleon, D
Abstract: Brain tumours are the most common solid tumours in children and a major cause of childhood mortality. The most common paediatric brain tumours include ependymomas, cerebellar astrocytomas and medulloblastomas. These brain tumours are highly heterogeneous regarding their histology, prognosis and therapeutic response. Subtle biochemical changes can be detected in intact tissues by High-Resolution Proton Magnetic Angle Spinning Spectroscopy (HR-MAS) revealing the status of tumour microheterogeneity and metabolic alterations before they are morphologically detectable. In this study, we present metabolic profiles by HR-MAS of 20 intact tissue samples from paediatric brain tumours. Tumour types include ependymoma, medulloblastoma and pilocytic astrocytoma. The metabolic characterization of paediatric brain tumour tissue by HR-MAS spectroscopy provided differential patterns for these tumours. The metabolic composition of the tumour tissue was highly consistent with previous in vivo and ex vivo studies. Some resonances detected in this work and not previously observed by in vivo spectroscopy also show potential in determining tumour type and grade (fatty acids, phenylalanine, glutamate). Overall, this work suggests that the additional information obtained by NMR metabolic profiling applied to tissue from paediatric brain tumours may be useful for assessing tumour grade and determining optimum treatment strategies.
Subject: paediatric brain tumors
pilocytic astrocytoma
biochemical profiling
High-Resolution Proton Magnetic Angle Spinning Spectroscopy
metabolic profiling
Country: Grécia
Editor: Spandidos Publ Ltd
Rights: embargo
Identifier DOI: 10.3892/ijmm_00000546
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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