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http://repositorio.unicamp.br/jspui/handle/REPOSIP/56097
Type: | Artigo de periódico |
Title: | Clobazam as add-on therapy in children with epileptic encephalopathy |
Author: | Silva, RC Montenegro, MA Guerreiro, CAM Guerreiro, MM |
Abstract: | Rationale: Clobazam has been used successfully in adults and children with partial epilepsy. The purpose of this study was to evaluate the safety and efficacy of clobazam as add-on therapy in children with epileptic encephalopathy. Methods: This was a retrospective study conducted at the pediatric epilepsy clinic of our university hospital. Children less than 18-years of age with epileptic encephalopathy were included in the study. Clobazam was introduced as add-on therapy, starting with 5 mg/Kg/day and increased in minimally effective doses, up to the maximum tolerated dose. Data were obtained from clinical files and follow-up visits. Results: Ninety-seven patients were included in the study (39 girls), aged between 1 and 17-years-old (mean = 9.9). Twenty-six patients had Lennox-Gastaut syndrome, seven had myoclonic astatic epilepsy, nine had West syndrome and, in 57 patients, the type of epileptic encephalopathy could not be determined. Clobazam dosage ranged from 5 to 60 mg/day (mean = 37.5 mg/day). Forty (41%) patients presented with adverse events, most of which were mild and transitory, and clobazam needed to be withdrawn in only 11 patients. Nine (9.2%) patients were seizure-free after clobazam adjunctive therapy. In 11 (11.3%) patients seizure improvement was > 75%, in 16 (16.5%) it was > 50%, in 17 (17.5%) improvement was < 50% and in 44 (45.5%) there was no change in seizure frequency. Three patients were lost to follow-up. In 85% of the patients with seizure improvement, the results lasted for more than one year. Conclusion: Clobazam is safe and effective in the treatment of epileptic encephalopathies of childhood. |
Country: | Canadá |
Editor: | Canadian Journal Neurological Sciences Inc |
Citation: | Canadian Journal Of Neurological Sciences. Canadian Journal Neurological Sciences Inc, v. 33, n. 2, n. 209, n. 213, 2006. |
Rights: | fechado |
Date Issue: | 2006 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
Files in This Item:
File | Description | Size | Format | |
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WOS000237346900015.pdf | 136.06 kB | Adobe PDF | View/Open |
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