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Type: Artigo de periódico
Title: Clobazam as add-on therapy in children with epileptic encephalopathy
Author: Silva, RC
Montenegro, MA
Guerreiro, CAM
Guerreiro, MM
Abstract: Rationale: Clobazam has been used successfully in adults and children with partial epilepsy. The purpose of this study was to evaluate the safety and efficacy of clobazam as add-on therapy in children with epileptic encephalopathy. Methods: This was a retrospective study conducted at the pediatric epilepsy clinic of our university hospital. Children less than 18-years of age with epileptic encephalopathy were included in the study. Clobazam was introduced as add-on therapy, starting with 5 mg/Kg/day and increased in minimally effective doses, up to the maximum tolerated dose. Data were obtained from clinical files and follow-up visits. Results: Ninety-seven patients were included in the study (39 girls), aged between 1 and 17-years-old (mean = 9.9). Twenty-six patients had Lennox-Gastaut syndrome, seven had myoclonic astatic epilepsy, nine had West syndrome and, in 57 patients, the type of epileptic encephalopathy could not be determined. Clobazam dosage ranged from 5 to 60 mg/day (mean = 37.5 mg/day). Forty (41%) patients presented with adverse events, most of which were mild and transitory, and clobazam needed to be withdrawn in only 11 patients. Nine (9.2%) patients were seizure-free after clobazam adjunctive therapy. In 11 (11.3%) patients seizure improvement was > 75%, in 16 (16.5%) it was > 50%, in 17 (17.5%) improvement was < 50% and in 44 (45.5%) there was no change in seizure frequency. Three patients were lost to follow-up. In 85% of the patients with seizure improvement, the results lasted for more than one year. Conclusion: Clobazam is safe and effective in the treatment of epileptic encephalopathies of childhood.
Country: Canadá
Editor: Canadian Journal Neurological Sciences Inc
Citation: Canadian Journal Of Neurological Sciences. Canadian Journal Neurological Sciences Inc, v. 33, n. 2, n. 209, n. 213, 2006.
Rights: fechado
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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