Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/56092
Type: Artigo de periódico
Title: Clinicopathological features and proliferation markers in tongue squamous cell carcinomas
Author: Gueiros, LA
Coletta, RD
Kowalski, LP
Lopes, MA
Abstract: The aim of this study was to evaluate the clinicopathological features and immunohistochemical expression of proliferation markers in oral tongue squamous cell carcinomas (OTSCC). Sixty-three patients without previous treatment or distant metastases were selected. Clinical information was retrieved from medical charts, histopathological analysis was performed and expression of proliferation markers (Ki-67, Mcm-2 and geminin) was evaluated. Most patients were men (81%) (male:female ratio 4.25:1). The age range was 31-92 years (mean 57.6 +/- 11.81 years). A high Anneroth score was associated with tumour size (p = 0.05), tumoural embolization of the blood vessels = 0.003), nodal metastasis (p = 0.05), nodal capsule rupture (p = 0.016) and distant metastasis (p = 0.002). Elevated Bryne scores were significantly associated with nodal capsule rupture (p = 0.02), distant metastasis (p = 0.002), shorter overall survival (OS) (p = 0.03) and disease-free survival (DFS) (p = 0.05) compared with patients with lower score. Elevated Ki-67+ cells (p = 0.05) and Mcm-2+ cells (p = 0.008) were associated with nodal metastasis and tumours with a high geminin score demonstrated a significant tendency for neural invasion (p = 0.05). Anneroth and Bryne score in association with biomarkers of proliferation can be useful for evaluating the biological behaviour of OTSCC.
Subject: tongue neoplasms
cell proliferation
biological marker
histological grading
Country: Escócia
Editor: Churchill Livingstone
Rights: fechado
Identifier DOI: 10.1016/j.ijom.2010.12.008
Date Issue: 2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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