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|Type:||Artigo de periódico|
|Title:||Clinicopathological features and proliferation markers in tongue squamous cell carcinomas|
|Abstract:||The aim of this study was to evaluate the clinicopathological features and immunohistochemical expression of proliferation markers in oral tongue squamous cell carcinomas (OTSCC). Sixty-three patients without previous treatment or distant metastases were selected. Clinical information was retrieved from medical charts, histopathological analysis was performed and expression of proliferation markers (Ki-67, Mcm-2 and geminin) was evaluated. Most patients were men (81%) (male:female ratio 4.25:1). The age range was 31-92 years (mean 57.6 +/- 11.81 years). A high Anneroth score was associated with tumour size (p = 0.05), tumoural embolization of the blood vessels = 0.003), nodal metastasis (p = 0.05), nodal capsule rupture (p = 0.016) and distant metastasis (p = 0.002). Elevated Bryne scores were significantly associated with nodal capsule rupture (p = 0.02), distant metastasis (p = 0.002), shorter overall survival (OS) (p = 0.03) and disease-free survival (DFS) (p = 0.05) compared with patients with lower score. Elevated Ki-67+ cells (p = 0.05) and Mcm-2+ cells (p = 0.008) were associated with nodal metastasis and tumours with a high geminin score demonstrated a significant tendency for neural invasion (p = 0.05). Anneroth and Bryne score in association with biomarkers of proliferation can be useful for evaluating the biological behaviour of OTSCC.|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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