Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/56073
Type: Artigo de periódico
Title: Clinical, genetic and microbiological findings in a Brazilian family with aggressive periodontitis
Author: Trevilatto, PC
Tramontina, VA
Machado, MAN
Goncalves, RB
Sallum, AW
Line, SRP
Abstract: Background, aim: Aggressive periodontitis comprises a group of rapidly progressive forms of periodontitis. Besides bacteria, a high level of subject susceptibility must be involved in the expression of disease. In the present study, we report the clinical, microbiological and genetic profile of a 14-individual family with aggressive periodontitis. Method: PCR was utilized to detect pathogenic bacteria of affected sites. DNA was obtained from epithelial cells through a mouthwash with 3% glucose and scrapping of the oral mucosa. RFLP-PCR was used to analyze cytokine genetic polymorphisms. Results: Localized aggressive periodontitis was diagnosed for an 18-year-old systemically healthy non-smoking proband, with siblings displaying aggressive periodontitis. Bacteroides forsythus and Treponema denticola were the most frequent pathogens. The proband presented Actinobacillus actinomycetemcomitans and detectable levels of Porphyromonas gingivalis, Bacteroides forsythus and Treponema denticola. Allele 2 of IL-1alpha (-889) polymorphism was found in all individuals as well as allele 1 of the IL-1beta (+3953) gene. Alleles 1 and 2 (50 each) of IL-1beta (-511), allele 1 of TNF-alpha (-308) and allele 2 (in homo or heterozygosity) of IL-RN (intron 2) gene were present. Conclusion: The results show that the present microbiological and genetic parameters were not relevant for the prediction of periodontitis susceptibility in this family.
Subject: aggressive periodontitis
cytokine
risk factors
gene polymorphism
periopathogens
Country: Dinamarca
Editor: Blackwell Munksgaard
Rights: fechado
Identifier DOI: 10.1034/j.1600-051x.2002.290309.x
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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