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Type: Artigo de periódico
Title: Clinical relevance and virulence factors of pigmented Serratia marcescens
Author: Carbonell, GV
Della Colleta, HHM
Yano, T
Darini, ALC
Levy, CE
Fonseca, BAL
Abstract: Pigmented Serratia marcescens isolated in a Brazilian hospital were studied with respect to frequency of isolation, serotyping, antibiotic resistance and virulence factors. The serotype most frequent was O6:K14(53%) and all isolates were resistant to ampicillin, cephalothin and tetracycline. The majority of the isolates (92%) were resistant to the action of human serum and all produced cytotoxins on Vero, CHO, HEp-2 and Mt La cells. These isolates were virulent for mice (LD50 = 10(7) bacteria ml(-1)) and showed virulence factors, but were isolated with low frequency (3.4%) and caused infection in only 31% of cases. Analysis of serotyping, phage typing and chromosomal DNA revealed at least 13 unrelated strains among pigmented S. marcescens. In conclusion, this work describes a low frequency of isolation of pigmented S. marcescens from clinical specimens, indicating that non-pigmented strains are clinically more significant. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Subject: nosocomial infection
virulence factor
pigmented Serratia marcescens
Country: Holanda
Editor: Elsevier Science Bv
Citation: Fems Immunology And Medical Microbiology. Elsevier Science Bv, v. 28, n. 2, n. 143, n. 149, 2000.
Rights: fechado
Identifier DOI: 10.1111/j.1574-695X.2000.tb01469.x
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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