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Type: Artigo de periódico
Title: Clinical and genetic risk factors for moderate hyperbilirubinemia in Brazilian newborn infants
Author: Mezzacappa, MA
Facchini, FP
Pinto, AC
Cassone, AEL
Souza, DS
Bezerra, MAC
Albuquerque, DM
Saad, STO
Costa, FF
Abstract: Objective: To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life. Study Design: Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency (G202A/A376G), and (TA)(n) UGT1A1 polymorphisms were established in a cohort of 608 Brazilian newborn infants. Hyperbilirubinemia was monitored until 134.5 +/- 49.8 h of life (IQR, 111.0 to 156.7). The dependent variable was total bilirubinemia (TB) >= 12.9 mg per 100 ml estimated by transcutaneous or plasma bilirubin measurements. Result: The African variant of G6PD deficiency and (TA)(7)/(TA)(7) and (TA)(7)/(TA)(8) polymorphisms present in 6.1 and 12.0% of newborns, respectively, were not risk factors for moderate hyperbilirubinemia. Coexpression of G6DP deficiency and UGT1A1 polymorphisms occurred in 0.49% of the subjects. Independent clinical predictors for TB >= 12.9mg per 100 ml were gestational age <38 weeks and reference curve percentiles >P40th. Conclusion: In this study, G6PD deficiency and UGT1A1 gene promoter polymorphisms were not risk factors for moderate hyperbilirubinemia. Genetic factors may vary considerably in importance among different populations. Journal of Perinatology (2010) 30, 819-826; doi: 10.1038/jp.2010.48; published online 8 April 2010
Subject: UDP glucuronosyltransferase
G6PD (glucose-6-phosphate dehydrogenase deficiency)
neonatal hyperbilirubinemia
Country: EUA
Editor: Nature Publishing Group
Citation: Journal Of Perinatology. Nature Publishing Group, v. 30, n. 12, n. 819, n. 826, 2010.
Rights: fechado
Identifier DOI: 10.1038/jp.2010.48
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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