Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/55905
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleChronic pain in Machado-Joseph diseasept_BR
dc.contributor.authorFranca, MCpt_BR
dc.contributor.authorD'Abreu, Apt_BR
dc.contributor.authorFriedman, JHpt_BR
dc.contributor.authorNucci, Apt_BR
dc.contributor.authorLopes-Cendes, Ipt_BR
unicamp.author.emailicendes@unicamp.brpt_BR
unicamp.authorFranca, Marcondes C., Jr. D'Abreu, Anelyssa Lopes-Cendes, Iscia Univ Estadual Campinas, UNICAMP, Dept Med Genet, BR-13084971 Campinas, SP, Brazilpt_BR
unicamp.authorFranca, Marcondes C., Jr. D'Abreu, Anelyssa Nucci, Anamarli Univ Estadual Campinas, Dept Neurol, BR-13084971 Campinas, SP, Brazilpt_BR
unicamp.authorFriedman, Joseph H. Neurohlth, Warwick, RI, Englandpt_BR
unicamp.authorFriedman, Joseph H. Brown Univ, Sch Med, Dept Clin Neurosci, Providence, RI 02912 USApt_BR
dc.subject.wosMultiple System Atrophypt_BR
dc.subject.wosParkinsons-diseasept_BR
dc.subject.wosSensory Symptomspt_BR
dc.subject.wosScalept_BR
dc.subject.wosFeaturespt_BR
dc.subject.wosAtaxiapt_BR
dc.description.abstractBackground: Machado-Joseph disease (MJD) is one of the most common forms of neurodegenerative ataxia characterized by remarkable phenotypic heterogeneity. Although patients frequently report pain, systematic evaluation of this clinical feature is lacking. Objectives: To compare the frequency of chronic pain among patients with genetically confirmed MJD, an age- and sex-matched healthy control group, and a disease control group of patients with amyotrophic lateral sclerosis (ALS).Methods: We included 70 patients with MJD, 20 patients with ALS, and 70 control subjects from 2 clinical centers. All individuals underwent assessment with a standardized pain questionnaire. In addition, we used a visual analog scale to quantify pain intensity. Results: Thirty-three patients with MJD (47%), 3 patients with ALS (15%), and 6 controls (9%) reported chronic pain. Lower back pain preceded ataxia in 6 patients with MJD. Twenty-nine patients with MJD had daily pain, which was continuous in 23. The mean visual analog scale score was 6.1 in patients with MJD. Pain was musculoskeletal in 26 patients with MJD, dystonic in 2, neuropathic in 2, and mixed in 3. Typically, pain was lumbar (n=17) or in the lower limbs (n=15). We did not find significant differences regarding duration of disease, sex, or severity of ataxia among patients with MJD with and without chronic pain. Expanded (CAG)(n) tandem repeats were longer in patients with MJD who experienced chronic pain (67.3 vs 65.2; P=.04). Conclusions: In our series, pain was significantly more frequent in patients with MJD than in controls. Chronic pain was a frequent and often disabling complaint among patients with MJD. The lower back was the most frequently reported location of pain in patients with MJD.pt
dc.relation.ispartofArchives Of Neurologypt_BR
dc.relation.ispartofabbreviationArch. Neurol.pt_BR
dc.publisher.cityChicagopt_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Medical Assocpt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationDECpt_BR
dc.identifier.citationArchives Of Neurology. Amer Medical Assoc, v. 64, n. 12, n. 1767, n. 1770, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume64pt_BR
dc.description.issuenumber12pt_BR
dc.description.firstpage1767pt_BR
dc.description.lastpage1770pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0003-9942pt_BR
dc.identifier.wosidWOS:000251538300012pt_BR
dc.identifier.doi10.1001/archneur.64.12.1767pt_BR
dc.date.available2014-11-15T16:50:22Z
dc.date.available2015-11-26T16:12:24Z-
dc.date.accessioned2014-11-15T16:50:22Z
dc.date.accessioned2015-11-26T16:12:24Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T16:50:22Z (GMT). No. of bitstreams: 1 WOS000251538300012.pdf: 70603 bytes, checksum: 545f296e1cbc67b15502f70ba844c478 (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:12:24Z (GMT). No. of bitstreams: 2 WOS000251538300012.pdf: 70603 bytes, checksum: 545f296e1cbc67b15502f70ba844c478 (MD5) WOS000251538300012.pdf.txt: 20404 bytes, checksum: 846e2b792d1ea85bc73d325bfe046867 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55905pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/55905
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55905-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000251538300012.pdf68.95 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.