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Type: Artigo
Title: Chronic nitric oxide inhibition as a model of hypertensive heart muscle disease
Author: Moreno, H.
Metze, K.
Zatz, R.
Bento, A.C.
De Nucci, G.
Antunes, E.
Abstract: We have compared the myocardial alterations in rats made hypertensive by the chronic inhibition of nitric oxide biosynthesis with those having renal hypertension (two kidney-one clip model), Male Wistar rats were chronically administered the nitric oxide synthase inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME) for 2, 4 and 8 weeks. Both groups initially developed a similar increase in blood pressure but only the 2K-1C rats developed myocardial hypertrophy after 2-4 weeks. L-NAME-treated animals developed a similar degree of hypertrophy following 8 weeks of treatment, As observed by light microscopy, the myocardial alterations in the latter animals consisted of extensive areas of fibrosis and myocardial necrosis: especially in regions of the subendocardium. The histological alterations induced by L-NAME were not caused by the accompanying hypertension, since the 2K-1C animals had a similar increase in arterial blood pressure without any significant alterations in the heart morphology. 2K-1C rats treated chronically with L-NAME behaved in a manner similar to the L-NAME-treated animals with regard to both the blood pressure increases and cardiac morphological alterations. Animals which received the inactive enantiomer D-NAME did not develop hypertension nor did they have any morphological abnormalities. Both the coronary flow and the contractile capacity of hearts isolated from rats treated viiith L-NAME for 8 weeks were impaired compared to control animals. These results indicate that the chronic inhibition of NO biosynthesis causes cardiac ischemia associated with a mechanical dysfunction that is unrelated to cardiac hypertrophy which is similar to those seen in some patients suffering from chronic arterial hypertension
Subject: Endotélio
Isquemia miocárdica
Hipertrofia ventricular esquerda
NG-nitroarginina metil éster
Country: Alemanha
Editor: Springer
Citation: Basic Research In Cardiology. Dr Dietrich Steinkopff Verlag, v. 91, n. 3, n. 248, n. 255, 1996.
Rights: fechado
Identifier DOI: 10.1007/BF00788911
Date Issue: 1996
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

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