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Type: Artigo de periódico
Title: Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice
Author: Cazita, PM
Berti, JA
Aoki, C
Gidlund, M
Harada, LM
Nunes, VS
Quintao, ECR
Oliveira, HCF
Abstract: Reduced estrogen levels result in loss of protection from coronary heart disease in postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is known about the role of CETP-ovarian hormone interactions in atherogenesis. We assessed the severity of diet-induced atherosclerosis in ovariectomized (OV) CETP transgenic mice crossbred with LDL receptor knockout mice. Compared with OV CETP expressing ((+)), OV CETP non-expressing ((-)) mice had higher plasma levels of total, VLDr-, LDL-, and HDL-cholesterol, as well as higher antibodies titers against oxidized LDL. The mean aortic lesion area was 2-fold larger in OV CETP- than in OV CETP+ mice (147 +/- 90 vs. 73 +/- 42 x 10(3) mum(2), respectively). Estrogen therapy in OV mice blunted the CETP dependent differences in plasma lipoproteins, oxLDL antibodies, and atherosclerosis severity. Macrophages from OV CETP+ mice took up less labeled cholesteryl ether (CEt) from acetyl-LDL than macrophages from OV CETP- mice. Estrogen replacement induced a further reduction in CEt uptake and an elevation in HDL mediated cholesterol efflux from pre-loaded OV CETP+ as compared with OV CETP- macrophages. These findings support the proposed anti-atherogenic role of CETP in specific metabolic settings.
Subject: LDL receptor knockout mice
CETP transgenic mice
lecithin cholesterol acyl transferase
oxidized LDL
phospholipid transfer protein
Country: EUA
Editor: Lipid Research Inc
Rights: fechado
Identifier DOI: 10.1194/jlr.M100440-JLR200
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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