Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/55788
Type: Artigo de periódico
Title: Blood spotlight on leukocytes and obesity
Author: Carvalheira, JBC
Qiu, YF
Chawla, A
Abstract: The rise of obesity and its attendant pathological sequelae, including type 2 diabetes and coronary artery disease, constitute an ongoing public health catastrophe in both the developed and, more recently, the developing world. Although the underlying pathophysiology is complex, chronic low-grade inflammation has emerged as a central driver of both primary metabolic dysfunction and subsequent tissue failure. Importantly, this inflammation has been shown to arise as a consequence of both the disruption of homeostatic tissue resident leukocytes and the recruitment of antagonistic effector cells from the circulation. In this review, we discuss the roles of visceral adipose tissue's salient leukocyte lineages in the transition to obesity and highlight key points at which this emerging immune axis may be manipulated for therapeutic effect.
Country: EUA
Editor: Amer Soc Hematology
Rights: fechado
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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