Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/55787
Type: Artigo de periódico
Title: Blood protein adsorption on sulfonated chitosan and kappa-carrageenan films
Author: Lima, PHL
Pereira, SVA
Rabello, RB
Rodriguez-Castellon, E
Beppu, MM
Chevallier, P
Mantovani, D
Vieira, RS
Abstract: Many strategies have been reported to improve compatibility of biopolymers using chemical and physical modifications. One possibility is the introduction of sulfonate groups (R-SO3-) in the chitosan chain. Another biopolymer with similar characteristics to those of heparin is kappa-carrageenan. This study proposed to investigate the application of these two polymers, based on their potential for globular protein adsorption (BSA and fibrinogen). Polymeric films of chitosan and kappa-carrageenan were prepared: all films were characterized by elemental analyses, FTIR, XPS and SEM. Characterization techniques showed that the chitosan chain was modified and confirmed the existence of sulfonate groups, as well as in the kappa-carrageenan chain, indicating surfaces with similar chemical properties to those of heparin. The effect of charge density was observed for each adsorption condition (BSA at pH 5.0 and 7.4). A more pronounced adsorption rate was observed at pH 5.0 than at pH 7.4 and equilibrium adsorption was achieved, in both cases, after approximately 20 min. The equilibrium data indicate a lower adsorption rate for the sulfonated chitosan film, in comparison to the other films. These results confirm the potential of modified chitosan for use in applications in which globular protein adsorption should be avoided. (C) 2013 Elsevier B.V. All rights reserved.
Subject: Chitosan
Carrageenan
Protein adsorption
Blood device
Antithrombogenic
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.colsurfb.2013.06.002
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.