Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/55780
Type: Artigo de periódico
Title: Blood amino acids concentration during insulin induced hypoglycemia in rats: the role of alanine and glutamine in glucose recovery
Author: Garcia, RF
Gazola, VAFG
Barrena, HC
Hartmann, EM
Berti, J
Toyama, MH
Boschero, AC
Carneiro, EM
Manso, FC
Bazotte, RB
Abstract: Our purpose was to determine the blood amino acid concentration during insulin induced hypoglycemia (IIH) and examine if the administration of alanine or glutamine could help glycemia recovery in fasted rats. IIH was obtained by an intraperitoneal injection of regular insulin (1.0U/kg). The blood levels of the majority of amino acids, including alanine and glutamine were decreased ( P< 0.05) during IIH and this change correlates well with the duration than the intensity of hypoglycemia. On the other hand, the oral and intraperitoneal administration of alanine (100mg= kg) or glutamine (100mg= kg) accelerates glucose recovery. This effect was partly at least consequence of the increased capacity of the livers from IIH group to produce glucose from alanine and glutamine. It was concluded that the blood amino acids availability during IIH, particularly alanine and glutamine, play a pivotal role in recovery from hypoglycemia.
Subject: amino acids
alanine
glutamine
gluconeogenesis
hypoglycemia
insulin
Country: EUA
Editor: Springer
Rights: fechado
Identifier DOI: 10.1007/s00726-006-0397-8
Date Issue: 2007
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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