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Type: Artigo de periódico
Title: Biotransformation of Phenylacetonitrile to 2-Hydroxyphenylacetic Acid by Marine Fungi
Author: de Oliveira, JR
Mizuno, CM
Seleghim, MHR
Javaroti, DCD
Rezende, MOO
Landgraf, MD
Sette, LD
Porto, ALM
Abstract: Marine fungi belonging to the genera Aspergillus, Penicillium, Cladosporium, and Bionectria catalyzed the biotransformation of phenylacetonitrile to 2-hydroxyphenylacetic acid. Eight marine fungi, selected and cultured with phenylacetonitrile in liquid mineral medium, catalyzed it quantitative biotransformation to 2-hydroxyphenylacetic acid. In this study, the nitrile group was firstly hydrolysed, and then, the aromatic ring was hydroxylated, producing 2-hydroxyphenylacetic acid with 51 % yield isolated. In addition, the 4-fluorophenylacetonitrile was exclusively biotransformed to 4-fluorophenylacetic acid by Aspergillus sydowii Ce19 (yield = 51 %). The enzymatic biotransformation of nitriles is not trivial, and here, we describe an efficient method for production of phenylacetic acids in mild conditions.
Subject: Nitrile
Marine fungi
Country: EUA
Editor: Springer
Rights: fechado
Identifier DOI: 10.1007/s10126-012-9464-1
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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