Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/55703
Type: Artigo de periódico
Title: BIOSYNTHESIS OF A TRYPANOCIDE BY CHROMOBACTERIUM-VIOLACEUM
Author: DURAN, N
ANTONIO, RV
HAUN, M
PILLI, RA
Abstract: Radio-isotope studies indicated not only that L-tryptophan can serve as carbon source for synthesis of the trypanocide, violacein by Chromobacterium violaceum (BB-78 strain) but also that isatin and indole 3-acetic acid are both important metabolic intermediates. Using 3-indolyl [2-C-14] and [1-C-14] acetic acid, it was found that the carboxylic carbon was not eliminated and that indole-3-acetic acid was incorporated intact into the pigment structure. N-Ethyl(5-hydroxy-indol-3-yl)-2-indolylethylamide is also an important metabolic intermediate in the violacein biosynthesis. This is the first report of a metabolic scheme for violacein synthesis which includes an intermediate other than L-tryptophan.
Subject: BIOSYNTHESIS
CARBOXAMIDES
CHROMOBACTERIUM VIOLACEUM
INDOLE-3-ACETIC ACID
TRYPANOCIDE
VIOLACEIN
Country: Inglaterra
Editor: Rapid Science Publishers
Rights: fechado
Identifier DOI: 10.1007/BF00327960
Date Issue: 1994
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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