Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/55577
Type: Artigo de periódico
Title: BIOGENIC SILVER NANOPARTICLES AND ITS ANTIFUNGAL ACTIVITY AS A NEW TOPICAL TRANSUNGUAL DRUG
Author: Marcato, PD
Duran, M
Huber, S
Rai, M
Melo, PS
Alves, OL
Duran, N
Abstract: Silver nanoparticles production was monitored by UV Vis and TEM micrograph and they were obtained as spherical and homogenous nanoparticles with a size of similar to 100 nm by photon correlation spectroscopy (PCS). Silver nanoparticles, in an IC80 range of 1-2 mu g/mL, showed significant antifungal activity against T. rubrum. Cytotoxicity through hemolytic activity against erythrocytes and the viability of V79 fibroblast or HL60 cells showed less toxicity than amphotericin B. The disk diffusion test showed that the silver nanoparticles exerted a similar inhibition zone that amphotericin B by a synergistic effect when added at the same time against T. rubrum culture.
Country: Suíça
Editor: Trans Tech Publications Ltd
Rights: fechado
Identifier DOI: 10.4028/www.scientific.net/JNanoR.20.99
Date Issue: 2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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