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Type: Artigo de periódico
Title: beta-1,3-Glucan given orally modulates immunomyelopoietic activity and enhances the resistance of tumour-bearing mice
Author: Torello, CO
Souza-Queiroz, J
Queiroz, MLS
Abstract: beta-Glucans have been reported to be potent adjuvants in stimulating innate and adaptive immune responses. The aim of the present study was to determine the immunohematopoietic effects of Imunoglucan (HEBRON) following its oral administration to normal and Ehrlich ascites tumour (EAT)-bearing mice. Mice were treated with 250, 500 and 1000mg/kg per day, p.o., Imunoglucan (beta-1,3-glucan extracted from Saccharomyces cerevisae) for 18 consecutive days. Treatment started 10days prior to and ended 8days after tumour inoculation. At 500 and 1000mg/kg per day, Imunoglucan enhanced the life span of EAT-bearing mice and prevented myelosuppression and splenomegaly caused by the tumour by increasing the number of granulocytemacrophage progenitors in the bone marrow and increasing colony-stimulating activity in the serum. At 500mg/kg, Imunoglucan restored the reduced ability of stromal cells to display myeloid progenitors in long-term bone marrow cultures of EAT-bearing mice and upregulated the production of interleukin (IL)-6 and IL-1 alpha by these cells, consistent with a higher number of non-adherent cells. Moreover, 500mg/kg Imunoglucan restored natural killer cell activity in tumour-bearing mice, consistent with the increased production of interferon (IFN)-gamma observed. The results of the present study suggest that Imunoglucan given orally indirectly modulates immune activity and probably disengages tumour-induced suppression by producing a higher reserve of myeloid progenitors in the bone marrow in consequence of biologically active cytokine release (colony-stimulating factors, IL-1 alpha, IL-6 and IFN-gamma).
Subject: colony forming unit-granulocyte
Ehrlich ascites tumour
long-term bone marrow culture
natural killer cells
serum colony-stimulating activity
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1111/j.1440-1681.2011.05655.x
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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