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Type: Artigo de periódico
Title: Benefits of Oxygen and Nitrogen Plasma Treatment in Vero Cell Affinity to Poly(Lactide-Co-Glycolide Acid)
Author: Esposito, AR
Kamikawa, CM
Lucchesi, C
Ferreira, BMP
Duek, EAD
Abstract: Cell adhesion on materials surface is critical because this phenomenon occurs before other events, as cell spreading, cell migration and cell differentiation. It is commonly accepted that the adhesion of cells on solid substrate is influenced by several substratum surface properties, such as wettability, surface charge, roughness and topography. Plasma technique is a convenient method for modifying surface properties of materials without affecting physical properties. In this study, poly(lactide-co-glycolide), PLGA, membranes were modified by oxygen and nitrogen plasma to improve polymer hydrophilicity and verify their effect on Vero cells culture. The PLGA membranes, which were characterized by SEM and contact angle, showed increased surface rugosity and narrower contact angles. Cell adhesion, cytotoxicity assay, SEM and cytochemistry analysis showed that plasma treatment was beneficial to cell growth by improving cell-polymer interaction.
Subject: biomaterials
plasma treatment
cell culture
Country: Brasil
Editor: Univ Fed Sao Carlos, Dept Engenharia Materials
Rights: aberto
Identifier DOI: 10.1590/S1516-14392013005000056
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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