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Type: Artigo de periódico
Title: Axonal sprouting in mdx mice and its relevance to cell and gene mediated therapies for Duchenne muscular dystrophy
Author: Neto, HS
Martins, AJ
Minatel, E
Marques, MJ
Abstract: We investigated whether pre-terminal axons and motor terminals retained their ability to sprout in the murine X-linked muscular dystrophy (mdx). Immunofluorescence confocal microscopy observation of nerve terminals and acetylcholine receptors in mdx muscles with crushed and non-crushed nerves showed that most of the junctions had intraterminal sprouting and that the number of junctions with extraterminal sprouting increased after the nerve crush lesion. Since new dystrophin-positive muscle fibers generated by cell-mediated therapies need to be innervated to proceed with their maturation and dystrophin production, these results suggest that the use of inducing factors to increase the sprouting capacity of nerve terminals could be an additional tool in the success of cell-mediated therapies. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Subject: confocal microscopy
nerve sprouting
neuromuscular junction
Country: Irlanda
Editor: Elsevier Sci Ireland Ltd
Rights: fechado
Identifier DOI: 10.1016/S0304-3940(03)00220-9
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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